MSc thesis: The effect of multiple myeloma progression in bone extracellular matrix
Stellenangebot vom 5. Juni 2020
Background: Biotechnology, Biomedical Engineering, Materials Science, Biomedicine, Biology or similar
Goal: To understand the effect of multiple myeloma (MM) in the bone extracellular matrix by
examining human bone biopsies at different stages of disease progression.
Multiple myeloma (MM) is a type of blood cancer in which plasma cells grow aberrantly and produce
abnormal antibodies. In the clinic, MM patients show lesions in the skeleton that do not heal, even
when the patient is in complete remission. MM cells mainly reside in the bone marrow and alter bone homeostasis by activating bone resorption and inhibiting bone formation. We are interested in understanding how these cancer cells alter the properties of the bone extracellular matrix at different stages of disease progression.
The project will involve documentation and analysis of human bone biopsies collected from patients who present several stages of this type of blood cancer. The analysis of these bone biopsies will be based in histology, immunohistochemistry, histomorphometry, confocal and electron microscopy. Exploratory analysis will involve immunohistochemistry to localize cancer cells in the tissue, histology and histomorphometry to characterize bone tissue composition, and confocal and electron microscopy to evaluate changes in the bone microstructure.
You should have a background in biotechnology, biomedical engineering, materials science, biomedicine, biology or similar, and strong interest in cancer biology. The project will be carried out at the Max Planck Institute of Colloids and Interfaces in the group of Dr Amaia Cipitria together with Dr Inés Moreno. This project is part of a collaboration with the oncologist Prof. Dr. med. Franziska Jundt, Universitätsklinikum Würzburg.
Please send your application including a motivation letter, your CV and a transcript of your university record to these two email addresses: firstname.lastname@example.org and
email@example.com. Please indicate “Master thesis – bone extracellular matrix multiple myeloma” in the subject line. The project can start at the beginning of July 2020. The working language is English.
Dr Amaia Cipitria (Emmy Noether Group Leader) and Dr Inés Moreno (Humboldt Postdoctoral
researcher), Dept. of Biomaterials, Max Planck Institute of Colloids and Interfaces, Golm, Potsdam.