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Dr. Christoph Rademacher
Group Leader
Phone:+49 331 567-9358

Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam

Structural Glycobiology

Room: 0.176

Structural Glycobiology

Structural Glycobiology

The  Research Group “Structural Glycobiology” has a strong focus on protein-ligand interactions using biophysical and computational techniques. In particular, we are interested in glycan-binding proteins, developing small molecular inhibitors as well as studying the recognition of their natural carbohydrate ligands. These findings are combined with functional studies of glycan-binding proteins in their native environment to foster our understanding of glycobiology in a structural context.

Research

The  Research Group “Structural Glycobiology” has a strong focus on protein-ligand interactions using biophysical and computational techniques. In particular, we are interested in glycan-binding proteins, developing small molecular inhibitors as well as studying the recognition of their natural carbohydrate ligands. These findings are combined with functional studies of glycan-binding proteins in their native environment to foster our understanding of glycobiology in a structural context. [more]
<div id="main_content_3_block" class="edit_text_block" title="Absatz bearbeiten" data-attr="main_content" data-block="main_content_3_block" data-id="38314">Dr. Christoph Rademacher, Dr. Robert Wawrzinek, Jonas Aretz, Jonas Hanske, Eike Wamhoff, Jessica Schulze, Hannes Baukmann, Henrik Schmidt, Stefanie Irmer-Stooff</div>

Group Members

Dr. Christoph Rademacher, Dr. Robert Wawrzinek, Jonas Aretz, Jonas Hanske, Eike Wamhoff, Jessica Schulze, Hannes Baukmann, Henrik Schmidt, Stefanie Irmer-Stooff
[more]
<ol class="list">
<li><span>Hanske, J., Aleksić, S., Ballaschk, M., Jurk, M., </span><span>Shanina, E., Beerbaum, M., Schmieder, P., Keller, B.G., </span><span>Rademacher, C</span><span>.</span><span> </span><span>(2016) </span><span>An</span><span> </span><span>intra-domain allosteric network modulates the calcium affinity of the</span><span> </span><span>C-type lectin receptor Langerin. </span><span>J Am</span><span> </span><span>Chem Soc</span><span>,</span><span> accepted.</span></li>
<li>Wamhoff, E.C., Hanske, J., Schnirch, L., Aretz, J., Grube, M., Varon Silva, D., Rademacher C. (2016) <sup>19</sup>F NMR-guided design of glycomimetic Langerin ligands. <em>ACS Chem Biol, accepted</em><a class="external" href="#__target_object_not_reachable"><br /></a></li>
<li>Aretz J, Kondo Y, Honda K, Anumala UR, Nazaré M, Watanabe N, Osada H,  Rademacher C, Chemical fragment arrays for rapid druggability assessment. Chem Comm, 2016, accepted</li>
</ol>

Publications

  1. Hanske, J., Aleksić, S., Ballaschk, M., Jurk, M., Shanina, E., Beerbaum, M., Schmieder, P., Keller, B.G., Rademacher, C. (2016) An intra-domain allosteric network modulates the calcium affinity of the C-type lectin receptor Langerin. J Am Chem Soc, accepted.
  2. Wamhoff, E.C., Hanske, J., Schnirch, L., Aretz, J., Grube, M., Varon Silva, D., Rademacher C. (2016) 19F NMR-guided design of glycomimetic Langerin ligands. ACS Chem Biol, accepted
  3. Aretz J, Kondo Y, Honda K, Anumala UR, Nazaré M, Watanabe N, Osada H,  Rademacher C, Chemical fragment arrays for rapid druggability assessment. Chem Comm, 2016, accepted
[more]
Drug Discovery Seminar<br />Glycobiology Lecture and Seminar

Teaching

Drug Discovery Seminar
Glycobiology Lecture and Seminar [more]
 
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