contact

profile_image
Dr. Christoph Rademacher
Group Leader
Phone:+49 331 567-9358

Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam

Structural Glycobiology

Room: 0.176

Structural Glycobiology

Structural Glycobiology

The  Research Group “Structural Glycobiology” has a strong focus on protein-ligand interactions using biophysical and computational techniques. In particular, we are interested in glycan-binding proteins, developing small molecular inhibitors as well as studying the recognition of their natural carbohydrate ligands. These findings are combined with functional studies of glycan-binding proteins in their native environment to foster our understanding of glycobiology in a structural context.

Research

The  Research Group “Structural Glycobiology” has a strong focus on protein-ligand interactions using biophysical and computational techniques. In particular, we are interested in glycan-binding proteins, developing small molecular inhibitors as well as studying the recognition of their natural carbohydrate ligands. These findings are combined with functional studies of glycan-binding proteins in their native environment to foster our understanding of glycobiology in a structural context. [more]
<div id="main_content_3_block" class="edit_text_block" title="Absatz bearbeiten" data-attr="main_content" data-block="main_content_3_block" data-id="38314">Dr. Christoph Rademacher, Dr. Robert Wawrzinek, Jonas Aretz, Eike Wamhoff, Jessica Schulze, Hannes Baukmann, Felix Fuchsberger, Henrik Schmidt, Melanie Gebauer</div>

Group Members

Dr. Christoph Rademacher, Dr. Robert Wawrzinek, Jonas Aretz, Eike Wamhoff, Jessica Schulze, Hannes Baukmann, Felix Fuchsberger, Henrik Schmidt, Melanie Gebauer
[more]
<ol class="list">
<li><span>Hanske J. et al. (2016) Bacterial polysaccharide specificity of the pattern recognition receptor Langerin is highly species dependent. <em>J Biol Chem, accepted</em><br /></span></li>
<li><span>Hanske, J. et al.</span><span> </span><span>(2016) </span><span>An</span><span> </span><span>intra-domain allosteric network modulates the calcium affinity of the</span><span> </span><span>C-type lectin receptor Langerin. </span><em>J Am Chem Soc, accepted.</em></li>
<li>Wamhoff, E.C.et al. (2016) <sup>19</sup>F NMR-guided design of glycomimetic Langerin ligands. <em>ACS Chem Biol, accepted</em></li>
<li>Aretz J. et al. (2016) Chemical fragment arrays for rapid druggability assessment. <em>Chem Comm, accepted</em></li>
</ol>

Publications

  1. Hanske J. et al. (2016) Bacterial polysaccharide specificity of the pattern recognition receptor Langerin is highly species dependent. J Biol Chem, accepted
  2. Hanske, J. et al. (2016) An intra-domain allosteric network modulates the calcium affinity of the C-type lectin receptor Langerin. J Am Chem Soc, accepted.
  3. Wamhoff, E.C.et al. (2016) 19F NMR-guided design of glycomimetic Langerin ligands. ACS Chem Biol, accepted
  4. Aretz J. et al. (2016) Chemical fragment arrays for rapid druggability assessment. Chem Comm, accepted
[more]
Drug Discovery Seminar<br />Glycobiology Lecture and Seminar

Teaching

Drug Discovery Seminar
Glycobiology Lecture and Seminar [more]
 
loading content