| Academic Qualifications: |
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Ph.D. Degree: |
July 1997- January 2002 |
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Thesis title: |
Development and Evaluation of resorbable biphasic calcium phosphate ceramics as bone replacement materials (Highly Commended), University of Madras, Chennai, India |
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M.Sc. in Physics: |
July 1994 – May 1996, University of Madras, Chennai, India |
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Diploma in Business Computer Applications: |
1994 - 1996 |
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| Work Experiences: |
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Since February 2004 |
Post Doctoral Research Fellow at Department of Biomaterials, Max-Planck Institute of Colloids and Interfaces, 14476, Germany. |
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June 2002 - October 2003 |
Wissenschaftlicher Mitarbeiter, Institute of Materials Science and Technology, Friedrich Schiller University, Jena, Germany |
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November 2000 - May 2002 |
Senior Research Fellow, Bio-Products Lab, Central Leather Research Institute, Chennai, India |
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November 1997 - October 2001 |
Research Student (NS), Department of Nuclear Physics, University of Madras, Chennai, India |
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February 1997 - October 1997 |
Project Assistant, UGC Career Award Project, Department of Nuclear Physics, University of Madras, Chennai, India |
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| Current Research Projects: |
| Bone Replacement Scaffolds |
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An ideal scaffolding material for bone tissue engineering should replicate the bone anatomy at microscopic level with interconnected micro and macro pores and with a similar composition of nanocomposite and should be able to promote the osteoblast proliferation and expression of the osteoblastic phenotype. Solid freeform fabrication or rapid prototyping (RP) is a technology by which a complex three dimensional (3D) structures can be produced directly from computer generated (CAD) design. CAD and RP together can be used to control the macro and micro-architecture of porous scaffolds.
We aim at developing a 3D polymeric composite scaffold with defined internal architecture by RP method. The biopolymer, Chitosan is used, along with hydroxyapatite to form composite scaffolds. Cell attachment, proliferation and differentiation over time on a material are indication of cellular compatibility of the material and determine the suitability of the material for tissue engineering application. To asses the biological response of these scaffolds in vitro, osteoblast-like cells were seeded on them. The response of the cells on composite scaffold is assessed by its proliferation rate and histological analysis. The structure of the scaffold allows more cells to grow compared to two-dimensional matrices.
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| Structure-Function-Property Relation in Bone and its Correlation to Diseases |
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This project is in close collaboration with the Ludwig Boltzmann Institute of Osteology in Vienna, Austria. The project deals with understanding the correlation of nano mechanical properties of diseased bone with its nano-structure, such as osteolathyrism and osteoporosis. The methodologies used are quantitative back-scattered electron imaging (qBEI), scanning nanoindentation and small-angle x-ray scattering techniques.
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| Other Research Interests are: |
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Processing and physico-chemical characteristaion of
-Biomimetic apatite formation in polymeric substrates
-Calcium phosphates, Ceramic-Polymeric composite
-Wound Healing materials.
-In-vivo evaluation of the bone substitute materials
-Biocompatibility evaluation using fibroblast and osteoblasts.
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| Papers Published in Journals: |
- Bone In-growth Induced by Biphasic Calcium Phosphate Ceramic in Femoral Defect of Dogs
I.Manjubala, R.V. Suresh Kumar, T.P.Sastry
Journal of Biomaterials Application 2005, (in press)
- Adhesion and proliferation of osteoblastic cells seeded on chitosan - hydroxyapatite porous scaffolds
I. Manjubala1, I. Ponomarev, K. D. Jandt, I. Wilke
European Cells and Materials 2004, 7(1), S64.
- Structural and morphological analysis of functionally graded calcium phosphate bioceramic
Manjubala I, Sastry TP
Key Engineering Materials 2002, 218-2, 89-91.
- Preparation, characterization and in-vitro release of gentamicin from coralline hydroxyapatite-chitosan composite microspheres.
Sivakumar M, Manjubala I, Rao KP
Carbohydrate Polymers 2002, 49 (3), 281-288.
- Bioactivity and osseointegration study of calcium phosphate ceramic of different chemical composition
I. Manjubala, M. Sivakumar, R.V. Sureshkumar and T.P. Sastry
J Biomedical Materials Research: Applied Biomaterials 2002, 63(2), 200-208.
- In-Situ formation of biphasic calcium phosphate ceramics using microwave irradiation
I. Manjubala and M. Sivakumar
Materials Chemistry and Physics 2001, 71(3), 272-278
- Biocompatibility Evaluation of biphasic calcium phosphate ceramics - An in-vivo study
I. Manjubala, R.V. Suresh Kumar and T.P. Sastry
Trends in Biomaterials and Artificial Organs, 2001, 14(2) 24-26.
- Preparation of Biphasic calcium phosphate doped with magnesium fluoride for osteoporotic applications
I. Manjubala and T.S. Sampath Kumar
Journal of Material Science Letters 2001, 20, 1225-1227.
- Effect of TiO2-Ag2O on the formation of calcium phosphate based functionally graded bioceramics
I. Manjubala and T.S. Sampath Kumar
Biomaterials 2000, 21, 1995-2002
- Synthesis of carbonated calcium phosphate using microwave irradiation
T.S. Sampath Kumar, I. Manjubala and J. Gunasekaran
Biomaterials 2000, 21, 1623-1629
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| Awards/Honours: |
i) Received "Senior Research Fellowship" from Council of Scientific and Industrial Research, Govt. of India. (Nov. 2000 - June 2002)
ii) Received "Outstanding Student Research Award " for the paper presented at Sixth World Biomaterials Congress held at Hawaii, USA during May 15-20, 2000
iii) Received "Bajpai - Saha Award" for paper presentation at XIth National Conference of the Society for Biomaterials and Artificial Organs held at IIT, Kharagpur , Dec 6-8, 2000
iv) Received "Young Research Award" at 5th International Conference in Asia of the International Union for Materials Research Soceity (IUMRS-ICA '98), held at Bangalore, Oct. 13-18, 1998.
v) Received "Outstanding Young Person" Award by Madras - Junior Chamber in 1999
vi) Received "Best Outgoing Student" for Best All-Rounder during 1991-94 in B.Sc. Course
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