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Selected Publications
Oligosaccharide Synthesis and Automated Carbohydrate Assembly
1. Plante, O.J.; Palmacci, E.R.; Seeberger, P.H.;
Automated Solid-Phase Synthesis of Oligosaccharides;
Science 2001, 291, 1523-1527.
2. Plante, O.J.; Palmacci, E.R.; Andrade, R.B.; Seeberger, P.H.;
Oligosaccharide Synthesis Using Glycosyl Phosphate and Dithiophosphate Triesters as Glycosylating Agents;
J. Am. Chem. Soc. 2001, 123, 9545-9554.
3. Love, K.R.; Seeberger, P.H.;
Automated Solid-Phase Synthesis of Protected Tumor-Associated Antigen and Blood Group Determinant Oligosaccharides;
Angew. Chem. Int. Ed. 2004, 43, 602-605.
4. Werz, D.B.; Castagner, B.; Seeberger, P.H.;
Automated Synthesis of the Tumor-Associated Carbohydrate Antigens Gb3 and Globo H: Incorporation of α -Galactosidic Linkages;
J. Am. Chem. Soc. 2007, 129, 2770-2771.
5.Codee, J.D.C.; Kröck, L.; Castagner, B.; Seeberger, P.H.;
Automated Solid-Phase Synthesis of Protected Oligosaccharides Containing beta-Mannosidic Linkages;
Chem. Eur. J. 2008, 14, 3987-3994.
Chemistry and Biology of Heparin
6. Orgueira, H.A.; Bartolozzi, A.; Schell, P.H.; Seeberger, P.H.;
Stereocontrol of Glycosylation Reactions by Conformational Locking of the Glycosyl Acceptor in Disaccharide Formation;
Angew. Chem. Int. Ed. 2002, 41, 2128-2131.
7. Orgueira, H.A.; Bartolozzi, A.; Schell, P.H.; Litjens, R.; Palmacci, E.R.; Seeberger, P.H.;
Modular Synthesis of Heparin Oligosaccharides;
Chem. Eur. J. 2003, 9, 140-169.
8. de Paz, J.L.; Noti, C.; Seeberger, P.H.;
Microarrays of Synthetic Heparin Oligosaccharides;
J. Am. Chem. Soc. 2006, 128, 2766-2767.
9. De Paz, J.L.; Moseman, E.A.; Noti, C.; Polito, L.; von Andrian, U.H.; Seeberger, P.H.;
Profiling Heparin-Chemokine Interactions Using Synthetic Tools;
ACS Chem. Biol., 2007, 2, 735-744.
10. de Paz, J.L.; Noti, C.; Boehm-Knoche, F.; Werner, S.; Seeberger, P.H.;
Glycodendrimers Containing Synthetic Heparin Oligosaccharides to Regulate Heparin-Mediated Biological Processes;
Chem. Biol. 2007, 14, 879-887.
GPI Anchors and Development of a Malaria Vaccine
11. Schofield, L.; Hewitt, M.C.; Evans, K.; Siomos, M.A.; Seeberger, P.H.;
Synthetic GPI as a Candidate Anti-toxic Vaccine in a Model of Malaria;
Nature, 2002, 418, 785-789.
12. Hewitt, M.C.; Snyder, D.A.; Seeberger, P.H.;
Rapid Synthesis of a Glycosylphosphatidylinositol-based Malaria Vaccine Using an Automated Solid-Phase Oligosaccharide Synthesizer;
J. Am. Chem. Soc. 2002, 124, 13434-13436.
13. Liu, X.; Kwon, Y.-U.; Seeberger, P.H.;
Convergent Chemical Synthesis of a Fully Lipidated Glycosylphosphatidylinositol Anchor of Plasmodium falciparum;
J. Am. Chem. Soc. 2005, 127, 5004-5005.
14. Kamena, F.; Tamborrini, M.; Liu, X.; Kwon, Y.-U.; Thompson, F.; Pluschke, G.; Seeberger; P.H.;
Synthetic GPI array to study antitoxic malaria response;
Nature Chem. Bio., 2008, 4, 238-240.
15. Brattig, N.W.; Kowalsky, K.; Liu, X.; Burchard, G.D.; Kamena, F.; Seeberger, P.H.;
Plasmodium falciparum glycosylphosphatidylinositol toxin interacts with the membrane of non-parasitized red blood cells: a putative mechanism contributing to malaria anemia;
Microb. Infect. 2008, 10, 885-891.
16. Becker, C.F.W.; Liu, X.; Olschewski, D.; Castelli, R.; Seidel, R.; Seeberger, P.H.;
Semisynthesis of a Glycosylphosphatidylinositol-Anchored Prion Protein;
Angew. Chem. Int. Ed. 2008, 47, 8215-8219.
Carbohydrate Arrays and Glycomics Tools
17. Adams, E.W.; Uberfeld, J.; Ratner, D.M.; O’Keefe, B.R.; Walt, D.R.; Seeberger, P.H.;
Encoded Fiber Optic Microsphere Arrays for Probing Protein-Carbohydrate Interactions;
Angew. Chem. Int. Ed. 2003, 42, 5317-5320.
18. Ratner, D.M.; Adams, E.W.; Su, J.; O’Keefe, B.R.; Mrksich, M.; Seeberger, P.H.;
Probing Protein-Carbohydrate Interactions with Microarrays of Synthetic Oligosaccharides;
ChemBioChem. 2004, 5, 379-383.
19. Disney, M.D.; Magnet, S.; Blanchard, J.S.; Seeberger, P.H.
Aminoglycoside Microarrays to Study Antibiotic Resistance,
Angew. Chem. Int. Ed. 2004, 43, 1591-1594.
20. Adams, E.W.; Ratner, D.M.; Bokesh, H.R.; McMahon, J.B.; O`Keefe, B.R.; Seeberger, P.H.
Oligosaccharide and Glycoprotein Microarrays as Tools in HIV-Glycobiology: Glycan Dependent gp120 / protein Interactions,
Chem Biol. 2004, 11, 875-881.
21. Ratner, D.M.; Adams, E. W.; Disney, M. D.; Seeberger, P.H.;
Tools for Glycomics: Mapping Interactions of Carbohydrates in Biological Systems;
ChemBioChem. 2004, 5, 1375-1383.
22. Disney, M.D.; Zheng, J.; Swager, T.; Seeberger, P.H.;
Visual Detection of Bacteria with Carbohydrate Containing Fluorescent Polymers,
J. Am. Chem. Soc. 2004, 126, 13343-13346.
23. Disney, M.D.; Seeberger, P.H.;
The Use of Carbohydrate Microarrays to Study Carbohydrate-Cell Interactions and to Detect Pathogens;
Chem. Biol. 2004, 11, 1701-1707.
24. Noti, C.; de Paz, J.L.; Polito, L.; Seeberger, P.H.;
Preparation and Use of Microarrays Containing Synthetic Heparin Oligosaccharides for the Rapid Analysis of Heparin-Protein Interactions;
Chem. Eur. J. 2006, 12, 8664-8686.
Vaccines Against Infectious Diseases
25. Werz, D.B.; Seeberger, P.H.;
First Total Synthesis of a Bacillus Anthracis Tetrasaccharide Antigen – Creation of an Anthrax Vaccine;
Angew. Chem. Int. Ed. 2005, 44, 6315-6318.
26. Liu, X.; Stocker, B.L.; Seeberger, P.H.;
Total Synthesis of Phosphatidylinositol Mannosides of Mycobacterium tuberculosis;
J. Am. Chem. Soc. 2006, 128, 3638-3648.
27. Liu, X.; Siegrist, S.; Amacker, M.; Zurbriggen, R.; Pluschke, G.; Seeberger, P.H.;
Enhancement of the Immunogenicity of Synthetic Carbohydrates by Conjugation to Virosomes - A Leishmaniasis Vaccine Candidate,
ACS Chem. Biol., 2006, 1, 161-164.
28. Tamborrini, M.; Werz, D. B.; Frey, J.; Pluschke, G.; Seeberger, P.H.;
Anti-Carbohydrate Antibodies for the Detection of Anthrax Spores;
Angew. Chem. Int. Ed. 2006, 45, 6581-6582.
Microreactors as Tools for Organic Chemists
29. Snyder, D.A.; Noti, C.; Seeberger, P.H.; Schael, F.; Bieber, T.; Rimmel, G.; Ehrfeld, W.;
Modular Microreaction Systems for Homogeneously and Heterogeneously Catalyzed Chemical Synthesis;
Helv. Chim. Acta. 2005, 88, 1-9.
30. Ratner, D.M., Murphy, E.R.; Jhunjhunwala, M.; Snyder, D.A; Jensen, K.F.; Seeberger, P.H.;
Microreactor-based Reaction Optimization in Organic Chemistry – Glycosylation as a Challenge;
Chem. Comm. 2005, 578-581.
31. Flögel, O.; Codée, J.D.C.; Seebach, D.; Seeberger, P.H.;
Microreactor Synthesis of β-Peptides;
Angew. Chem. Int. Ed. 2006, 45, 7000-7003.
32. Carrel, F.R.; Geyer, K.; Codée, J.D.C.; Seeberger, P.H.;
Oligosaccharide Synthesis in Microreactors;
Organic Letters 2007, 9, 2285-2288.
33. Gustafsson, T.; Pontén, F.; Seeberger, P.H.;
Trimethylaluminum Mediated Amide Bond Formation in a Continuous Flow Microreactor as Key to the Synthesis of Rimonabant and Efaproxiral;
Chem. Comm. 2008, 1100-1102.
34. Gustafsson, T.; Gilmour, R.; Seeberger, P.H.;
Fluorination Reactions in Microreactors;
Chem. Comm. 2008, 3022-3024.
35. Odedra, A.; Geyer, K; Gustafsson, T.; Gilmour, R.; Seeberger, P.H.;
Fast and Efficient Radical Based-Reduction and Hydrosilylation Reactions in a Microreactor Using Trimethylsilylhyride;
Chem. Comm. 2008, 3025-3027.
De novo Carbohydrate Synthesis
36. Timmer, M.S.M.; Adibekian, A.; Seeberger, P.H.;
Short DeNovo Synthesis of Fully Functionalized Uronic Acid Monosaccharides;
Angew. Chem.Int. Ed. 2005, 44, 7605-7607.
37. Adibekian, A.; Bindschädler, P.; Timmer, M.S.M.; Noti, C.; Schützenmeister, N.; Seeberger, P.H.;
De Novo Synthesis of Uronic Acid Building Blocks for the Assembly of Heparin Oligosaccharides;
Chem. Eur. J. 2007, 13, 4510-4522.
Carbohydrates for Delivery and Use as Adjuvants
38. Adams, E.W.; Ratner, D.M.; Seeberger, P.H.; Hacohen, N.;
Carbohydrate-Mediated Targeting of Antigen to Dendritic Cells Leads to Enhanced Presentation of Antigen to T Cells;
Chem.Bio.Chem. 2008, 9, 294-303.
Reviews
39. Noti, C.; Seeberger, P.H.;
Chemical Approaches to Define Structure-Activity Relationships of heparin-like Glycosaminoglycans;
Chem. Biol. 2005, 12, 731-756.
40. Seeberger, P.H.; Werz, D.B.;
Automated Synthesis of Oligosaccharides as Basis for Drug Discovery;
Nature Rev. Drug. Disc. 2005, 4, 751-763.
41. Seeberger, P.H.;
Exploring Life’s Sweet Spot;
Nature 2005, 437, 1239-1239.
42. Geyer, K.; Codee, J.D.C.; Seeberger, P.H.;
Microreactors as Tools for Synthetic Chemists – The Chemists’ Round-Bottom Flask of the 21st Century?;
Chem. Eur. J. 2006, 12, 8434-8442.
43. Seeberger, P.H.; Werz, D.B.;
Synthesis and Medical Applications of Oligosaccharides;
Nature 2007, 446, 1046-1051.
44. Seeberger, P.H.;
Automated Oligosaccharide Synthesis;
Chem Soc. Rev. 2008, 37, 19-28.
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