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Proteins and Membranes
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Current experiments in biophysics, biochemistry, and biology provide data of increasing resolution and precision. Biophysical modeling plays a central role in interpreting or complementing these data.
Our research is focused on the development of models for the folding and binding of proteins and the adhesion of membranes.
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Recent reviews
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Transition states in protein folding
TR Weikl. Commun Comput Phys 7, 283-300 (2010) [pdf]
Adhesion of membranes via receptor-ligand complexes: Domain formation, binding cooperativity and active processes
TR Weikl, M Asfaw, H Krobath, B Rozycki, R Lipowsky. Soft Matter 5, 3213-3224 (2009) [pdf]
Loop-closure principles in protein folding
TR Weikl. Arch Biochem Biophys 469, 67-75 (2008) [pdf]
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Selected publications
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Constructing the equilibrium ensemble of folding pathways from short off-equilibrium simulations.
F Noe, C Schuette, E Vanden-Eijnden, L Reich, TR Weikl. PNAS 106, 19011-19016 (2009) [pdf][supplementary information]
Selected-fit versus induced-fit protein binding: Kinetic differences and mutational analysis.
TR Weikl, C von Deuster. Proteins 75, 104-110 (2009) [pdf]
Binding cooperativity of membrane adhesion receptors.
H Krobath, B Rozycki, R Lipowsky, TR Weikl. Soft Matter 5, 3354-3361 (2009) [pdf]
Effective surface interactions mediated by adhesive particles.
B Rozycki, R Lipowsky, TR Weikl. Europhys Lett 84, 26004 (2008) [pdf]
Stable patterns of membrane domains at corrugated substrates.
B Rozycki, TR Weikl, R Lipowsky. Phys Rev Lett 100, 098103 (2008) [pdf]
Transition states in protein folding: Modeling phi-values of small beta-sheet proteins.
TR Weikl. Biophys J 94, 929-937 (2008) [pdf]
Transition states in protein folding kinetics: The structural interpretation of phi-values.
TR Weikl and KA Dill, J Mol Biol (2007) [pdf]
Adhesion of membranes with active stickers.
B Rozycki, R Lipowsky, TR Weikl, Phys Rev Lett 96, 048101 (2006) [pdf][appendix][Pressemitteilung]
Phi-values in protein-folding kinetics have energetic and structural components.
C Merlo, KA Dill, TR Weikl, PNAS 102, 10171-10175 (2005) [pdf][press release][Pressemitteilung]
Pattern formation during T cell adhesion.
TR Weikl, R Lipowsky, Biophys J 87, 3665-3678 (2004) [pdf]
Folding rates and low-entropy-loss routes of two-state proteins.
TR Weikl, KA Dill, J Mol Biol 329, 585-598 (2003) [pdf]
Indirect interactions of membrane-adsorbed cylinders.
TR Weikl, Eur Phys J E 12, 265-273 (2003) [pdf]
Fluctuation-induced aggregation of rigid membrane inclusions.
TR Weikl, Europhys Lett 54, 547-553 (2001) [pdf]
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| © 2012, Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Potsdam |
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