Publikationen

We routinely use glycan arrays for different applications. A selection of recent original research articles are listed below. Please contact us with a project proposal if you are interested in access to our screening platform.

2019

1.
Garg, M.; Stern, D.; Groß, U.; Seeberger, P. H.; Seeber, F.; Varón Silva, D.: Detection of anti-Toxoplasma gondii antibodies in human sera using synthetic glycosylphosphatidylinositol glycans on a bead-based multiplex assay. Analytical Chemistry 91 (17), S. 11215 - 11222 (2019)


2018

2.
Menova, P.; Sella, M.; Sellrie, K.; Pereira, C. L.; Seeberger, P. H.: Identification of the minimal glycotope of Streptococcus pneumoniae 7F capsular polysaccharide using synthetic oligosaccharides. Chemistry – A European Journal 24 (16), S. 4181 - 4187 (2018)

2017

3.
Lisboa, M. P.; Khan, N.; Martin, C.; Xu, F.-F.; Reppe, K.; Geissner, A.; Govindan, S.; Witzenrath, M.; Pereira, C. L.; Seeberger, P. H.: Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5. Proceedings of the National Academy of Sciences of the United States of America 114 (42), S. 11063 - 11068 (2017)
4.
Ruprecht, C.; Bartetzko, M.; Senf, D.; Dallabernardina, P.; Boos, I.; Andersen, M. C. F.; Kotake, T.; Knox, J. P.; Hahn, M. G.; Clausen, M. H. et al.; Pfrengle, F.: A synthetic glycan microarray enables epitope mapping of plant cell wall glycan-directed antibodies. Plant Physiology 175 (3), S. 1094 - 1104 (2017)
5.
Hanske, J.; Wawrzinek, R.; Geissner, A.; Wamhoff, E.-C.; Sellrie, K.; Schmidt, H.; Seeberger, P. H.; Rademacher, C.: Calcium-independent activation of an allosteric network in Langerin by heparin oligosaccharides. ChemBioChem: A European Journal of Chemical Biology 18 (13), S. 1183 - 1187 (2017)

2016

6.
Parameswarappa, S. G.; Reppe, K.; Geißner, A.; Ménová, P.; Govindan, S.; Calow, A. D. J.; Wahlbrink, A.; Weishaupt, M. W.; Monnanda, B. P.; Bell, R. et al.; Pirofski, L.-A.; Suttorp, N.; Sander, L.; Witzenrath, M.; Pereira, C. L.; Chakkumkal, A.; Seeberger, P. H.: A semi-synthetic oligosaccharide conjugate vaccine candidate confers protection against Streptococcus pneumoniae serotype 3 infection. Cell Chemical Biology 23 (11), S. 1407 - 1416 (2016)
7.
Geißner, A.; Pereira, C. L.; Leddermann, M.; Chakkumkal, A.; Seeberger, P. H.: Deciphering antigenic determinants of Streptococcus pneumoniae serotype 4 capsular polysaccharide using synthetic oligosaccharides. ACS Chemical Biology 11 (2), S. 335 - 344 (2016)
8.
Broecker, F.; Hanske, J.; Martin, C. E.; Baek, J. Y.; Wahlbrink, A.; Wojcik, F.; Hartmann, L.; Rademacher, C.; Chakkumkal, A.; Seeberger, P. H.: Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans. Nature Communications 7, 11224 (2016)
9.
Bröcker, F.; Martin, C. E.; Wegner, E.; Mattner, J.; Baek, J. Y.; Pereira, C. L.; Chakkumkal, A.; Seeberger, P. H.: Synthetic lipoteichoic acid glycans are potential vaccine candidates to protect from Clostridium difficile infections. Cell Chemical Biology 23 (8), S. 1014 - 1022 (2016)
10.
Reinhardt, A.; Wehle, M.; Geißner, A.; Crouch, E. C.; Kang, Y.; Yang, Y.; Chakkumkal, A.; Santer, M.; Seeberger, P. H.: Structure binding relationship of human surfactant protein D and various lipopolysaccharide inner core structures. Journal of Structural Biology 195 (3), S. 387 - 395 (2016)

2015

11.
Schmidt, D.; Schuhmacher, F.; Geissner, A.; Seeberger, P. H.; Pfrengle, F.: Automated synthesis of arabinoxylan-aligosaccharides enables characterization of antibodies that recognize plant cell wall glycans. Chemistry – A European Journal 21 (15), S. 5709 - 5713 (2015)
12.
Pereira, C. L.; Geißner, A.; Chakkumkal, A.; Seeberger, P. H.: Chemical synthesis elucidates the immunological importance of a pyruvate modification in the capsular polysaccharide of Streptococcus pneumoniae serotype 4. Angewandte Chemie International Edition 54, S. 10016 - 10019 (2015)

2014

13.
Götze, S.; Azzouz, N.; Tsai, Y.-H.; Groß, U.; Reinhardt, A.; Anish, C.; Seeberger, P. H.; Silva, D. V.: Diagnosis of toxoplasmosis using a synthetic glycosylphosphatidylinositol glycan. Angewandte Chemie, International Edition in English 53 (50), S. 13701 - 13705 (2014)
14.
Mietzsch, M.; Broecker, F.; Reinhardt, A.; Seeberger, P. H.; Heilbronn, R.: Differential adeno-associated virus serotype-specific interaction patterns with synthetic heparins and other glycans. Journal of Virology 88 (5), S. 2991 - 3003 (2014)
15.
Maglinao, M.; Eriksson, M.; Schlegel, M. K.; Zimmermann, S.; Johannssen, T.; Götze, S.; Seeberger, P. H.; Lepenies, B.: A platform to screen for C-type lectin receptor-binding carbohydrates and their potential for cell-specific targeting and immune modulation. Journal of Controlled Release 175, S. 36 - 42 (2014)
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