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Biomembranes and more

Last modified:  13/8/18, 10:50 AM

Since more than a decade now, giant vesicles are objects that fascinate and, at times, surprise us. These giants are only a few tens of microns in size and this defines their unique property: they are visible under a light microscope and provide a handy biomimetic tool for displaying directly the response of the membrane on the cell-size scale. Our group employs them for systematic measurements of the properties of lipid bilayers as a function of membrane composition and phase state, surrounding media, and temperature. We also investigate membrane responses to external factors such as ions, amphiphilic (biomacro)molecules and polymers, membrane-wetting aqueous phases, hydrodynamic flows or electromagnetic fields. The objectives of our group are to understand fundamental cellular phenomena and morphologies of cell organelles as well as to identify general mechanisms underlying cellular processes.

…And apart from being focused on our work, we also have fun.


Charged giant unilamellar vesicles prepared by electroformation exhibit nanotubes and transbilayer lipid asymmetry, Steinkühler et al. Sci. Rep.  DOI: 10.1038/s41598-018-30286-z

Micron-sized domains in quasi single-component giant vesicles, Knorr et al., Biochim. Biophys. Acta - Biomembr. DOI: 10.1016/j.colsurfa.2018.05.011

The glycolipid GM1 reshapes asymmetric biomembranes and giant vesicles by curvature generation, Dasgupta et al., Proc. Natl. Acad. Sci. USA. DOI: 10.1073/pnas.1722320115

Area increase and budding in giant vesicles triggered by light: behind the scene, Georgiev et al., Adv. Sci. DOI: 10.1002/advs.201800432

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