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DIMOVA LAB

Biomembranes and more

Last modified:  7/12/18, 10:50 AM

Since more than a decade now, giant vesicles are objects that fascinate and, at times, surprise us. These giants are only a few tens of microns in size and this defines their unique property: they are visible under a light microscope and provide a handy biomimetic tool for displaying directly the response of the membrane on the cell-size scale. Our group employs them for systematic measurements of the properties of lipid bilayers as a function of membrane composition and phase state, surrounding media, and temperature. The objectives of our group are to understand fundamental cellular phenomena and morphologies of cell organelles as well as to identify general mechanisms underlying cellular processes. If this grabbed your interest and you would like to learn more about giant vesicles, wait a bit for The Giant Vesicle Book coming soon - it will be both giant and about the giants.

…And apart from being focused on our work, we also have fun.

News

Asymmetric ionic conditions generate large membrane curvatures, Karimi et al. Nano Lett. DOI: 10.1021/acs.nanolett.8b03584

Charged giant unilamellar vesicles prepared by electroformation exhibit nanotubes and transbilayer lipid asymmetry, Steinkühler et al. Sci. Rep.  DOI: 10.1038/s41598-018-30286-z

Micron-sized domains in quasi single-component giant vesicles, Knorr et al., Biochim. Biophys. Acta - Biomembr. DOI: 10.1016/j.colsurfa.2018.05.011

The glycolipid GM1 reshapes asymmetric biomembranes and giant vesicles by curvature generation, Dasgupta et al., Proc. Natl. Acad. Sci. USA. DOI: 10.1073/pnas.1722320115

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Oct, 2018: Finally submitted The Giant Vesicle Book

Sept, 2018: Article about our work on How cells get their shape

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