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DIMOVA LAB

Biomembranes and more

The properties of lipid membranes are influenced by numerous factors. In the lab, we have a bunch of in-house developed experimental techniques to measure mechanical characteristics such as the bending rigidity (fluctuation analysis, micropipette aspiration, electrodeformation) and the stretching elasticity (micropipettes) of membranes. We have applied them to look at the effects of cholesterol [read more] or inserting peptides [read more]. Apart from that, we have previously elaborated approaches for measuring the edge tension in porated membranes [read more], the adhesion energy [read more], the capacitance of lipid and polymer membranes [read more], their shear surface viscosity [read more]. For a review on ways to assess the bending rigidity of membranes, see the following review:

● Recent developments in the field of bending rigidity measurements on membranes, R. Dimova, Adv. Coll. Interf. Sci., 208, 225–234 (2014) DOI: 0.1016/j.cis.2014.03.003 [Full text]

Membrane mechanical, rheological and electrical properties

a vesicle enclosing aqueous droplets (DIC)


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a vesicle with internal tubes (confocal cross section)

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a tough diblock-copolymer vesicle after being released from a micropipette (DIC)

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a multicomponent vesicle with domains (3D confocal

a palm-like vesicle

a wrinkled gel-phase vesicle after being crack-opened

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Last modified: 13-Nov-20 12:36:29 PM

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