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DIMOVA LAB

Biomembranes and more

Last modified:  1/6/17, 10:50 AM

Since more than a decade now, giant vesicles are objects that fascinate and, at times, surprise us. These giants are only a few tens of microns in size and this defines their unique property: they are visible under a light microscope and provide a handy biomimetic tool for displaying directly the response of the membrane on the cell-size scale. Our group employs them for systematic measurements of the properties of lipid bilayers as a function of membrane composition and phase state, surrounding media, and temperature. We also investigate membrane responses to external factors such as ions, amphiphilic (biomacro)molecules and polymers, membrane-wetting aqueous phases, hydrodynamic flows or electromagnetic fields. The objectives of our group are to understand fundamental cellular phenomena and morphologies of cell organelles as well as to identify general mechanisms underlying cellular processes.

…And apart from being focused on our work, we also have fun.

News

Copper ATPase CopA from Escherichia coli: Quantitative Correlation between ATPase Activity and Vectorial Copper Transport, Wijekoon et al. JACS (2017) in press DOI: 10.1021/jacs.6b12921

Giant vesicles exposed to aqueous two-phase systems: Membrane wetting, budding processes, and spontaneous tubulation, Dimova & Lipowsky, Adv Mater Interfaces 4:1600451 (2017) DOI: 10.1002/admi.201600451

GM1 softens POPC membranes and induces the formation of micron-sized domains, Fricke & Dimova, Biophys J 111:1935 (2016) DOI: 10.1016/j.bpj.2016.09.028


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May, 2017: John Brezovec joined the lab

April, 2017: Congratulations Dr. Vasko!

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