In biological cells, molecular motors transport various types of cargo particles such as vesicles,
organelles, and filaments. This cargo transport is performed by small teams consisting of several motor molecules.
If all motors belong to the same
molecular species, their cooperative action leads to uni-directional transport
with a strongly increased run length and a
characteristic force dependence of the velocity distributions
The run length may also be enhanced by crosslinking the cargo
to the filament via additional molecules that bind to and diffuse along the
In general, the motors interfere by mutual strain forces that act to pull the motors from
the filament or stall their preferred movement
If two antagonistic species of motors pull on the cargo in opposite directions, they perform a stochastic tug-of-war which induces several distinct patterns of bi-directional transport . Two important control parameters for such a tug-of-war are the overall motor numbers for the two motor species . The latter number can change by motors that hop on to and off from the cargo as observed in kinesin- and dynein-based transport of endosomes .
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Distinct transport regimes ... - Supporting Information.
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Bidirectional transport by molecular motors ... - Supporting material
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Motility states of molecular motors engaged in a stochastic tug-of-war.
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Tug-of-war as a cooperative mechanism ... - Supporting Information.
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Transport of beads by several kinesin motors.
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Cooperative cargo transport by several molecular motors.
Cooperative cargo transport ... - Supporting Information.
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