Biomembranes attract each other
via adhesion molecules and receptor/ligand bonds.
[1]
[2]
These molecular "stickers" can diffuse laterally within
the contact area of the membranes,
which implies that the molecular bonds can
form clusters, domains, and domain patterns.
[3]
[4]
The molecular mechanisms underlying these pattern formation processes may
be of entropic
[5]
or enthalpic
[2]
origin.
One particularly interesting example is provided by immunological synapses
which involve the active transport of adhesion molecules into the contact zone
[6].
In order to study these pattern formation processes, we introduced
lattice gas models on deformable surfaces
[1]
[4],
which automatically
incorporate the mutual exclusion between the molecules and provide an intuitive
understanding
of the observed behavior in terms of nucleation and growth processes.
The same approach also leads to a concise description for the binding
cooperativity of membrane-anchored molecules and to
a generalized 'law of mass action' for membrane adhesion
[7], with
binding constants that
are governed by the nanoscale roughness of the membranes
[8].
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-
Jinglei Hu, R. Lipowsky, and T. R. Weikl
Binding constants of membrane-anchored receptors
and ligands depend strongly on the nanoscale
roughness of membranes.
Binding constants of membrane-anchored receptors
and ligands ... - Supporting Information
PNAS 110, 15283-15288 (2013)
-
H. Krobath, B. Rózycki, R. Lipowsky, and T. R. Weikl
Line tension and stability of domains of long and short receptor-ligand
complexes in cell-adhesion zones.
PLoS ONE 6, e23284 (2011).
-
B. Rozycki, R. Lipowsky, and T. R. Weikl
Segregation of receptor-ligand complexes in cell adhesion zones:
phase diagrams and the role of thermal membrane roughness.
New J. Phys. 12, 095003 (2010).
-
T. R. Weikl, M. Asfaw, H. Krobath, B. Rozycki, and R. Lipowsky
Adhesion of membranes via receptor-ligand complexes: Domain formation,
binding cooperativity, and active processes.
Soft Matter 5, 3213-3224 (2009).
-
H. Krobath, B. Rozycki, R. Lipowsky, and T. R. Weikl
Binding cooperativity of membrane adhesion receptors.
Soft Matter 5, 3354 - 3361 (2009).
-
H. Krobath, G.J. Schütz, R. Lipowsky and T.R. Weikl
Lateral diffusion of receptor-ligand bonds in membrane adhesion zones: Effect of thermal membrane
roughness.
EPL 78, 38003 (2007).
-
B. Rozycki, T.R. Weikl and R. Lipowsky
Stochastic resonance for adhesion of membranes with active stickers.
Eur. Phys. J. E 22, 97 - 106 (2007).
-
T.R. Weikl and R. Lipowsky
Membrane Adhesion and Domain Formation.
In "Advances in Planar Lipid Bilayers and Liposomes'', Vol. 5,
ed. by A. Leitmannova Liu
(Elsevier, 2007) p. 64 -127.
-
M. Asfaw, B. Rozycki, R. Lipowsky and T.R. Weikl
Membrane adhesion via competing receptor/ligand bonds.
Europhys. Lett. 76, 703 - 709 (2006).
-
T. Franke, R. Lipowsky and W. Helfrich
Adhesion of lipid membranes induced by CrCl3.
Europhys. Lett. 76, 339 - 345 (2006).
-
B. Rozycki, T. Weikl and R. Lipowsky
Adhesion of Membranes via switchable molecules.
Phys. Rev. E 73, 061908 (2006).
-
B. Rozycki, R. Lipowsky and T. Weikl
Adhesion of Membranes with Active Stickers.
Adhesion of Membranes with Active Stickers - Appendices.
Phys. Rev. Lett. 96 , 048101-1 - 048101-4 (2006).
-
T.R. Weikl and R. Lipowsky
Pattern Formation during T-Cell Adhesion.
Biophys. J. 87, 3665 - 3678 (2004).
-
T. R. Weikl, J. T. Groves, and R. Lipowsky
Pattern formation during adhesion of multicomponent membranes.
Europhys. Lett. 59, 916-922 (2002).
-
R. Lipowsky.
Domains and Rafts in Membranes - Hidden Dimensions of
Selforganization.
J. Biological Phys. 28, 195-210 (2002).
-
T.R. Weikl, D. Andelman, S. Komura and R. Lipowsky
Adhesion of
membranes with competing specific and generic interactions.
Eur. Phys. J. E 8, 59-66 (2002).
-
T. Weikl, and R. Lipowsky.
Adhesion-induced phase behavior of multicomponent membranes.
Phys. Rev. E 64 , 011903 (2001).
-
T. Weikl, and R. Lipowsky.
Local adhesion of membranes to striped surface domains.
Langmuir 16 , 9338-9346 (2000).
-
T. Weikl, R. Netz, and R. Lipowsky.
Unbinding transitions and phase separation of multi-component
membranes.
Phys. Rev. E 62, R45-R48 (2000).
-
R. Lipowsky.
Flexible membranes with anchored polymers
Colloids and Surfaces A 128, 255-264 (1997).
-
R. Lipowsky.
Adhesion of membranes via anchored stickers.
Phys. Rev. Lett. 77 ,1652-1655
(1996).