Publications

Journal Article (44)

  1. 2018
    Ng, S.; Bennett, N. J.; Schulze, J.; Gao, N.; Rademacher, C.; Derda, R.: Genetically-encoded Fragment-based Discovery of Glycopeptide Ligands for DC-SIGN. Bioorganic & Medicinal Chemistry (2018)
  2. Ota, F.; Hirayama, T.; Kizuka, Y.; Yamaguchi, Y.; Fujinawa, R.; Nagata, M.; Ismanto, H. S.; Lepenies, B.; Aretz, J.; Rademacher, C. et al.; Seeberger, P. H.; Angata, T.; Kitazume, S.; Yoshida, K.; Betsuyaku, T.; Kida, K.; Yamasaki, S.; Taniguchi, N.: High affinity sugar ligands of C-type lectin receptor langerin. Biochimica et Biophysica Acta (BBA) - General Subjects 1862 (7), pp. 1592 - 1601 (2018)
  3. Sommer, R.; Wagner, S.; Rox, K.; Varrot, A.; Hauck, D.; Wamhoff, E.-C.; Schreiber, J.; Ryckmans, T.; Brunner, T.; Rademacher, C. et al.; Hartmann, R. W.; Brönstrup, M.; Imberty, A.; Titz, A.: Glycomimetic, orally bioavailable LecB inhibitors block biofilm formation of Pseudomonas aeruginosa. Journal of the American Chemical Society 140 (7), pp. 2537 - 2545 (2018)
  4. Tian, G.-Z.; Hu, J.; Zhang, H.-X.; Rademacher, C.; Zou, X.-P.; Zheng, H.-N.; Xu, F.; Wang, X.-L.; Yin, T. L. &. J.: Synthesis and conformational analysis of linear homo- and heterooligomers from novel 2-C-branched sugar amino acids (SAAs). Scientific Reports 8, 6625 (2018)
  5. Wamhoff, E.-C.; Schulze, J.; Bellmann, L.; Bachem, G.; Fuchsberger, F. F.; Rademacher, J.; Hermann, M.; Del Frari, B.; van Dalen, R.; Hartmann, D. et al.; van Sorge, N.; Seitz, O.; Stoitzner, P.; Rademacher, C.: A specific, glycomimetic Langerin ligand for human Langerhans cell targeting. bioRxiv (2018)
  6. 2017
    van Dalen, R.; Rumpret, M.; Fuchsberger, F. F.; van Teijlingen, N. H.; Hanske, J.; Rademacher, C.; Geijtenbeek, T. B.H.; van Strip, J. A.G.; Weidenmaier, C.; Peschel, A. et al.; van Sorge, N. M.: Wall teichoic acid is a pathogen-associated molecular pattern of Staphylococcus aureus that is recognized by langerin (CD207) on skin Langerhans cells. bioRxiv (2017)
  7. Glas, A.; Wamhoff, E.-C.; Krüger, D. M.; Rademacher, C.; Grossmann, T. N.: Increased Conformational Flexibility of a Macrocycle‒Receptor Complex Contributes to Reduced Dissociation Rates. Chemistry – A European Journal 23 (64), pp. 16157 - 16161 (2017)
  8. Spiliotopoulos, D.; Wamhoff, E.-C.; Lolli, G.; Rademacher, C.; Caflisch, A.: Discovery of BAZ2A bromodomain ligands. European Journal of Medicinal Chemistry 139 (Supplement C), pp. 564 - 572 (2017)
  9. Hanske, J.; Wawrzinek, R.; Geissner, A.; Wamhoff, E.-C.; Sellrie, K.; Schmidt, H.; Seeberger, P. H.; Rademacher, C.: Calcium-independent activation of an allosteric network in Langerin by heparin oligosaccharides. ChemBioChem: A European Journal of Chemical Biology 18 (13), pp. 1183 - 1187 (2017)
  10. Aretz, J.; Baukmann, H.; Shanina, E.; Hanske, J.; Wawrzinek, R.; Zapol'skii, V. A.; Seeberger, P. H.; Kaufmann, D. E.; Rademacher, C.: Identification of Multiple Druggable Secondary Sites by Fragment Screening against DC-SIGN. Angewandte Chemie International Edition 56 (25), pp. 7292 - 7296 (2017)
  11. Aretz, J.; Baukmann, H.; Shanina, E.; Hanske, J.; Wawrzinek, R.; Zapol'skii, V. A.; Seeberger, P. H.; Kaufmann, D. E.; Rademacher, C.: Identifikation sekundärer Bindestellen auf DC-SIGN mithilfe eines Fragment-Screenings. Angewandte Chemie 129 (25), pp. 7398 - 7402 (2017)
  12. Spiliotopoulos, D.; Zhu, J.; Wamhoff, E.-C.; Deerain, N.; Marchand, J.-R.; Aretz, J.; Rademacher, C.; Caflisch, A.: Virtual Screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain. Bioorganic & Medicinal Chemistry Letters 27 (11), pp. 2472 - 2478 (2017)
  13. Gao, C.; Fujinawa, R.; Yoshida, T.; Ueno, M.; Ota, F.; Kizuka, Y.; Hirayama, T.; Korekane, H.; Kitazume, S.; Maeno, T. et al.; Ohtsubo, K.; Yoshida, K.; Yamaguchi, Y.; Lepenies, B.; Aretz, J.; Rademacher, C.; Kabata, H.; Hegab, A. E.; Seeberger, P. H.; Betsuyaku, T.; Kida, K.; Taniguchi, N.: A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models. American Journal of Physiology - Lung Cellular and Molecular Physiology 312 (2), pp. L268 - L276 (2017)
  14. Hanske, J.; Schulze, J.; Aretz, J.; McBride, R.; Loll, B.; Schmidt, H.; Knirel, Y.; Rabsch, W.; Wahl, M. C.; Paulson, J. C. et al.; Rademacher, C.: Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent. The Journal of Biological Chemistry 292 (3), pp. 862 - 871 (2017)
  15. 2016
    Hanske, J.; Aleksić, S.; Ballaschk, M.; Jurk, M.; Shanina, E.; Beerbaum, M.; Schmieder, P.; Keller, B. G.; Rademacher, C.: Intradomain Allosteric Network Modulates Calcium Affinity of the C-Type Lectin Receptor Langerin. Journal of the American Chemical Society 138 (37), pp. 12176 - 12186 (2016)
  16. Wamhoff, E.-C.; Hanske, J.; Schnirch, L.; Aretz, J.; Grube, M.; Varón Silva, D.; Rademacher, C.: 19F NMR-Guided Design of Glycomimetic Langerin Ligands. ACS Chemical Biology 11 (9), pp. 2407 - 2413 (2016)
  17. Aretz, J.; Kondoh, Y.; Honda, K.; Anumala, U. R.; Nazaré, M.; Watanabe, N.; Osada, H.; Rademacher, C.: Chemical fragment arrays for rapid druggability assessment. Chemical Communications 52 (58), pp. 9067 - 9070 (2016)
  18. Broecker, F.; Hanske, J.; Martin, C. E.; Baek, J. Y.; Wahlbrink, A.; Wojcik, F.; Hartmann, L.; Rademacher, C.; Chakkumkal, A.; Seeberger, P. H.: Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans. Nature Communications 7, 11224 (2016)
  19. Aretz, J.; Wratil, P. R.; Wamhoff, E.-C.; Nguyen, H. G.; Reutter, W.; Rademacher, C.: Fragment-screening of N-acetylmannosamine kinase reveals non-carbohydrate inhibitors. Canadian Journal of Chemistry 94 (11), pp. 920 - 926 (2016)
  20. Mallagaray, A.; Rademacher, C.; Parra, F.; Hansman, G.; Peters, T.: Saturation transfer difference nuclear magnetic resonance titrations reveal complex multistep-binding of l-fucose to norovirus particles. Glycobiology 27 (1), pp. 80 - 86 (2016)
  21. 2015
    Aretz, J.; Rademacher, C.: Fragmentbasierte Wirkstoffentwicklung. Nachrichten aus der Chemie 63 (2), pp. 116 - 121 (2015)
  22. Lee, C.-U.; Hahne, G.; Hanske, J.; Bange, T.; Bier, D.; Rademacher, C.; Hennig, S.; Grossmann, T.: Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angewandte Chemie, International Edition 54, pp. 13796 - 13800 (2015)
  23. Lee, C.-U.; Hahne, G.; Hanske, J.; Bange, T.; Bier, D.; Rademacher, C.; Hennig, S.; Grossmann, T.: Redox-Modulation der PTEN-Phosphataseaktivität durch Wasserstoffperoxid und Bisperoxidovanadium-Komplexe. Angewandte Chemie 127 (46), pp. 14001 - 14005 (2015)
  24. 2014
    Aretz, J.; Wamhoff, E.-C.; Hanske, J.; Heymann, D.; Rademacher, C.: Computational and experimental prediction of human C-type lectin receptor druggability. Frontiers in immunology (2014)
  25. Glas, A.; Bier, D.; Hahne, G.; Rademacher, C.; Ottmann, C.; Grossmann, T.: Constrained Peptides with Target-Adapted Cross-Links as Inhibitors of a Pathogenic Protein-Protein Interaction. Angewandte Chemie International Edition 53 (9), pp. 2489 - 2493 (2014)
  26. Ponader, D.; Maffre, P.; Aretz, J.; Pussak, D.; Ninnemann, N. M.; Schmidt, S.; Seeberger, P. H.; Rademacher, C.; Nienhaus, G. U.; Hartmann, L.: Carbohydrate-Lectin Recognition of Sequence-defined Heteromultivalent Glycooligomers. Journal of the American Chemical Society 136 (5), pp. 2008 - 2016 (2014)
  27. Bröcker, F.; Aretz, J.; Yang, Y.; Hanske, J.; Guo, X.; Reinhardt, A.; Wahlbrink, A.; Rademacher, C.; Anish, C.; Seeberger, P. H.: Epitope Recognition of Antibodies against a Yersinia pestis Lipopolysaccharide Trisaccharide Component. ACS Chemical Biology 9 (4), pp. 867 - 873 (2014)
  28. 2013
    Rillahan, C. D.; Schwartz, E.; Rademacher, C.; McBride, R.; Rangarajan, J.; Fokin, V. V.; Paulson, J. C.: On-Chip Synthesis and Screening of a Sialoside Library Yields a High Affinity Ligand for Siglec-7. ACS Chemical Biology 8 (7), pp. 1417 - 1422 (2013)
  29. Kawasaki, N.; Vela, J. L.; Nycholat, C. M.; Rademacher, C.; Khurana, A.; van Rooijen, N.; Crocker, P. R.; Kronenberg, M.; Paulson, J. C.: Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation. Proceedings of the National Academy of Sciences of the United States of America 110 (19), pp. 7826 - 7831 (2013)
  30. Macauley, M. S.; Pfrengle, F.; Rademacher, C.; Nycholat, C. M.; Gale, A. J.; von Drygalski, A.; Paulson, J. C.: Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis. The Journal of Clinical Investigation 123 (7), pp. 3074 - 3083 (2013)
  31. 2012
    Rademacher, C.; Paulson, J. C.: Glycan Fingerprints: Calculating Diversity in Glycan Libraries. ACS Chemical Biology 7 (5), pp. 829 - 834 (2012)
  32. Fiege, B.; Rademacher, C.; Cartmell, J.; Kitov, P. I.; Parra, F.; Peters, T.: Molecular Details of the Recognition of Blood Group Antigens by a Human Norovirus as Determined by STD NMR Spectroscopy. Angewandte Chemie, International Edition in English 51 (4), pp. 928 - 932 (2012)
  33. Landström, J.; Persson, K.; Rademacher, C.; Lundborg, M.; Wakarchuk, W.; Peters, T.; Widmalm, G.: Small molecules containing hetero-bicyclic ring systems compete with UDP-Glc for binding to WaaG glycosyltransferase. Glycoconjugate Journal 29 (7), pp. 491 - 502 (2012)
  34. Nycholat, C. M.; Rademacher, C.; Kawasaki, N.; Paulson, J. C.: In Silico-Aided Design of a Glycan Ligand of Sialoadhesin for in Vivo Targeting of Macrophages. Journal of the American Chemical Society 134 (38), pp. 15696 - 15699 (2012)
  35. Rademacher, C.; Bru, T.; McBride, R.; Robison, E.; Nycholat, C. M.; Kremer, E. J.; Paulson, J. C.: A Siglec-like sialic-acid-binding motif revealed in an adenovirus capsid protein. Glycobiology 22 (8), pp. 1086 - 1091 (2012)
  36. Yu, B.; van Ingen, H.; Vivekanandan, S.; Rademacher, C.; Norris, S. E.; Freedberg, D. I.: More accurate 1JCH coupling measurement in the presence of 3JHH strong coupling in natural abundance. Journal of Magnetic Resonance 215, pp. 10 - 22 (2012)
  37. 2011
    Kawasaki, N.; Rademacher, C.; Paulson, J. C.: CD22 Regulates Adaptive and Innate Immune Responses of B Cells. Journal of Innate Immunity 3 (4), pp. 411 - 419 (2011)
  38. Rademacher, C.; Guiard, J.; Kitov, P. I.; Fiege, B.; Dalton, K. P.; Parra, F.; Bundle, D. R.; Peters, T.: Targeting Norovirus Infection-Multivalent Entry Inhibitor Design Based on NMR Experiments. Chemistry – A European Journal 17 (27), pp. 7442 - 7453 (2011)
  39. Zeng, Y.; Rademacher, C.; Nycholat, C. M.; Futakawa, S.; Lemme, K.; Ernst, B.; Paulson, J. C.: High affinity sialoside ligands of myelin associated glycoprotein. Bioorganic & Medicinal Chemistry Letters 21 (17), pp. 5045 - 5049 (2011)
  40. 2010
    Rademacher, C.; Landström, J.; Sindhuwinata, N.; Palcic, M. M.; Widmalm, G.; Peters, T.: NMR-based exploration of the acceptor binding site of human blood group B galactosyltransferase with molecular fragments. Glycoconjugate Journal 27 (3), pp. 349 - 358 (2010)
  41. 2008
    Rademacher, C.; Peters, T.: Molecular recognition of ligands by native viruses and virus-like particles as studied by NMR experiments. Topics in Current Chemistry-Series 273, pp. 183 - 202 (2008)
  42. Rademacher, C.; Krishna, N. R.; Palcic, M.; Parra, F.; Peters, T.: NMR experiments reveal the molecular basis of receptor recognition by a calicivirus. Journal of the American Chemical Society 130 (11), pp. 3669 - 3675 (2008)
  43. 2007
    Rademacher, C.; Shoemaker, G. K.; Kim, H.-S.; Zheng, R. B.; Taha, H.; Liu, C.; Nacario, R. C.; Schriemer, D. C.; Klassen, J. S.; Peters, T. et al.; Lowary, a. T. L.: Ligand specificity of CS-35, a monoclonal antibody that recognizes mycobacterial lipoarabinomannan: a model system for oligofuranoside-protein recognition. Journal of the American Chemical Society 129 (34), pp. 10489 - 10502 (2007)
  44. 2006
    Angulo, J.; Rademacher, C.; Biet, T.; Benie, A. J.; Blume, A.; Peters, H.; Palcic, M.; Parra, F.; Peters, T.: NMR analysis of carbohydrate-protein interactions. Glycomics, pp. 12 - 30 (2006)

Book (1)

  1. 2014
    Seeberger, P. H.; Rademacher, C. (Eds.): Carbohydrates as Drugs. Springer, Cham (2014), 237 pp.

Book item (1)

  1. 2016
    Rademacher, C.; Seeberger, P. H.: High-Throughput Synthesis of Diverse Compound Collections for Lead Discovery and Optimization. In: Handbook of Experimental Pharmacology, Vol. 232, pp. 73 - 89. Springer, Switzerland (2016)

Meeting Abstract (5)

  1. 2017
    van Dalen, R.; Rademacher, C.; Rumpret, M.; Geijtenbeek, T.; Weidenmaier, C.; Peschel, A.; van Sorge, N.: Skin Langerhans cells sense the human pathogen Staphylococcus aureus through the C-type lectin receptor langerin (CD207). In: European Journal of Immunology, Vol. 47, p. 32 - 32. 47th Annual Meeting of the German Society for Immunology, Erlangen, Germany, September 12, 2017. Wiley-VCH, Weinheim (2017)
  2. 2015
    Schulze, J.; Wamhoff, E.-C.; Rademacher, C.: Towards small molecule-based targeted delivery to immune cells. In: FEBS Journal, Vol. 282, p. 245 - 245. 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life, Berlin, Germany, July 04, 2015 - July 09, 2015. Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies, Oxford, UK (2015)
  3. 2014
    Aretz, J.; Wamhoff, E.-C.; Hanske, J.; Heymann, D.; Rademacher, C.: Druggability of mammalian C-type lectin receptors. In: Abstracts of Papers of the American Chemical Society, Vol. 248. 248th National Meeting of the American-Chemical-Society (ACS), San Francisco, CA, August 10, 2014 - August 14, 2014. (2014)
  4. Bröcker, F.; Martin, C.; Hanske, J.; Rademacher, C.; Pereira, C. L.; Anish, C.; Seeberger, P.: Deciphering Glycan-Antibody Interactions: towards a Carbohydrate-based Vaccine against Clostridium difficile. In: GLYCOBIOLOGY, Vol. 24, p. 1129 - 1129. Joint Meeting of the Society-for-Glycobiology (SFG) and the Japanese-Society-of-Carbohydrate-Research (JSCR), Honolulu, HI, November 16, 2014 - November 19, 2014. (2014)
  5. Fujinawa, R.; Ota, F.; Gao, C.; Hirayama, T.; Kabata, H.; Korekane, H.; Kitazume, S.; Ohtsubo, K.; Yoshida, K.; Yamguchi, Y. et al.; Lepenies, B.; Rademacher, C.; Betsuyaku, T.; Kida, K.; Taniguchi, N.: Binding of langerin/CD207 to keratan sulfate disaccharide, Gal (6SO3) β1, 4-GlcNAc (6SO3) and its triangle derivative in vitro and in vivo: possible drug targets for COPD (chronic obstructive pulmonary disease). In: GLYCOBIOLOGY, Vol. 24, p. 1218 - 1218. Joint Meeting of the Society-for-Glycobiology (SFG) and the Japanese-Society-of-Carbohydrate-Research (JSCR), Honolulu, HI, November 16, 2014 - November 19, 2014. (2014)
 
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