Proteins and Membranes
A key theme of our current research is protein binding. We investigate both the binding of soluble proteins to ligand molecules, and the binding of membrane-anchored proteins that mediate membrane-membrane adhesion. The central question in our projects on soluble proteins is how conformational changes affect the binding dynamics and functional dynamics. In our projects on membrane-anchored proteins, the main questions are how the thermal fluctuations of the membranes and the flexibility of the proteins and protein anchors affect the binding equilibrium and binding dynamics. In addition, we investigate the interactions of nanoparticles with membranes.