kontakt

profile_image
Dr. Thomas Weikl
Group Leader
Telefon:+49 331 567-9609Fax:+49 331 567-9612

Selected Publications

Binding constants of membrane-anchored receptors and ligands depend strongly on the nanoscale roughness of membranes
J Hu, R Lipowsky, TR Weikl TR. Proc. Natl. Acad. Sci. USA 110:15283-15288 (2013)

Tubulation and aggregation of spherical nanoparticles adsorbed on vesicles
AH Bahrami, R Lipowsky, TR Weikl. Phys. Rev. Lett. 109, 188102 (2012)

Conformational selection and induced changes along the catalytic cycle of E. Coli DHFR
TR Weikl, DD Boehr. Proteins 80, 2369-2383 (2012)

Segregation of receptor-ligand complexes in cell adhesion zones: phase diagrams and the role of thermal membrane roughness
B Rozycki, R Lipowsky, TR Weikl. New. J. Phys. 12, 095003 (2010)

Constructing the equilibrium ensemble of folding pathways from short off-equilibrium simulations.
F Noe, C Schütte, E Vanden-Eijnden, L Reich,  TR Weikl. Proc. Natl. Acad. Sci. USA 106, 19011-19016 (2009)

Binding cooperativity of membrane adhesion receptors
H Krobath, B Rozycki, R Lipowsky, TR Weikl. Soft Matter 5, 3354-3361 (2009)

Selected-fit versus induced-fit protein binding: Kinetic differences and mutational analysis
TR Weikl, C von Deuster. Proteins 75, 104-110 (2009)

Loop-closure principles in protein folding
TR Weikl. Arch Biochem Biophys 469, 67-75 (2008)

Phi-values in protein-folding kinetics have energetic and structural components
C Merlo, KA Dill, TR Weikl. PNAS 102, 10171-10175 (2005)

Proteins and Membranes

Proteins and Membranes

A key theme of our current research is protein binding. We  investigate both the binding of soluble proteins to ligand molecules, and the binding of membrane-anchored proteins that mediate membrane-membrane adhesion. The central question in our projects on soluble proteins is how conformational changes affect the binding dynamics and functional dynamics. In our projects on membrane-anchored proteins, the main questions are how the thermal fluctuations of the membranes and the flexibility of the proteins and protein anchors affect the binding equilibrium and binding dynamics. In addition, we investigate the interactions of nanoparticles with membranes.


<strong><strong><strong>Binding constants of membrane-anchored receptors and ligands depend strongly on the nanoscale roughness of membranes</strong><br /></strong></strong>Cooperative wrapping of nanoparticles<strong> <strong><br /></strong></strong>

Forschungsprojekte

Binding constants of membrane-anchored receptors and ligands depend strongly on the nanoscale roughness of membranes
Cooperative wrapping of nanoparticles
[mehr]
<strong>Gruppenleiter:</strong> Thomas Weikl<br /><strong>Mitarbeiter:</strong> Fabian Paul, Michael Raatz

Mitarbeiter

Gruppenleiter: Thomas Weikl
Mitarbeiter: Fabian Paul, Michael Raatz [mehr]
Journal Articles

Publikationen

Journal Articles
 
loading content