Molecular motors are able to
convert the chemical energy released from nucleotide hydrolysis into
mechanical work. This chemomechanical coupling exhibits some universal features
[1]
and has to satisfy several
thermodynamic constraints in the form of balance conditions
for the possible enzymatic
pathways or motor cycles
[2]
[3].
In fact, molecular motors with several catalytic domains are governed by
several competing motor cycles as has been explicitly shown for kinesin
[4]
[5]
and myosin V [6].
Two elastically coupled molecular motors are governed by rather complex chemomechanical
networks, which involve, however, only two parameters in addition to those that describe
the kinetics of a single motor
[7].
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-
A. Krukau, V. Knecht, and R. Lipowsky
Allosteric control of kinesin's motor domain by tubulin:
a molecular dynamics study.
Allosteric control of kinesin's motor domain by tubulin ... - Supporting
Information
Phys. Chem. Chem. Phys. 16, 6189-6198 (2014).
-
V. Bierbaum and R. Lipowsky
Dwell time distritubutions of the molecular motor myosin V.
PLoS ONE 8, e55366 (2013)
-
C. Keller, F. Berger, S. Liepelt, and R. Lipowsky
Network complexity and parametric simplicity for cargo transport by
two molecular motors.
J. Stat. Phys. 150, 205-234 (2013)
-
V. Bierbaum and R. Lipowsky
Chemomechanical coupling and motor cycles of myosin V.
Chemomechanical coupling ... of myosin V - Supporting Information.
Biophys. J. 100, 1747-1755 (2011).
-
S. Liepelt and R. Lipowsky
Impact of slip cycles on the operation modes and efficiency
of molecular motors.
J. Stat. Phys. 141, 1-16 (2010).
-
R. Lipowsky, S. Liepelt, and A. Valleriani
Energy conversion by molecular motors coupled to
nucleotide hydrolysis.
J. Stat. Phys. 135, 951-975 (2009).
-
S. Liepelt and R. Lipowsky
Operation modes of the molecular motor kinesin.
Phys. Rev. E 79, 011917 (2009).
-
A. Valleriani, S. Liepelt, and R. Lipowsky
Dwell time distributions for kinesin's mechanical steps.
EPL 82, 28011 (2008).
-
R. Lipowsky and S. Liepelt
Chemomechanical coupling of molecular motors: Thermodynamics,
network representations, and balance conditions.
J. Stat. Phys. 130, 39 - 67 (2008).
Chemomechanical coupling of molecular motors ... - Erratum.
J. Stat. Phys. 135, 777-778 (2009).
-
S. Liepelt and R. Lipowsky
Kinesin's network of chemomechanical motor cycles.
Phys. Rev. Lett. 98, 258102 (2007).
Kinesin's network of chemomechanical motor cycles - Appendices.
-
S. Liepelt and R. Lipowsky
Steady-state balance conditions for molecular motor cycles and stochastic nonequilibrium
processes.
EPL 77, 50002 (2007).
-
R. Lipowsky, Y. Chai, S. Klumpp, S. Liepelt and M.J.I. Müller
Molecular motor traffic: From biological nanomachines to macroscopic transport.
Physica A 372, 34 - 51 (2006).
-
R. Lipowsky and S. Klumpp
'Life is Motion': Multiscale motility of molecular motors.
Physica A 352, 53-112, (2005).
-
R. Lipowsky and N. Jaster
Molecular Motor Cycles: From ratchets to networks.
J. Stat. Phys. 110, 1141-1167 (2003).
-
R. Lipowsky.
Movements of molecular motors.
In "Biological Physics 2000" ed. by V. Sa-yakanit, L. Matsson,
and H. Frauenfelder
(World Scientific, Singapore 2001) p. 41-55.
-
R. Lipowsky.
Universal aspects of the chemo-mechanical coupling for molecular
motors.
Phys. Rev. Lett. 85 , 4401-4404 (2000).
-
R. Lipowsky.
Molecular motors and stochastic models
In ''Stochastic Processes in Physics, Chemistry, and Biology'',
ed. by J.A. Freund and T. Pöschel,
''Lecture Notes in Physics'', Vol. 557,
pages 21 - 31
(Springer, Berlin 2000).
-
R. Lipowsky and T. Harms.
Molecular motors and nonuniform ratchets.
Eur. Biophys. J. 29 , 542-548 (2000).
-
T. Harms and R. Lipowsky.
Driven Ratchets with Frozen Disorder.
Phys. Rev. Lett. 79 , 2895-2898 (1997).
