Publications
Journal Article (72)
2023
Journal Article
12, e69415 (2023)
Information transfer in mammalian glycan-based communication. eLife 2022
Journal Article
5 (5), pp. 2185 - 2192 (2022)
Synthetic glyconanoparticles modulate innate immunity but not the complement system. ACS applied bio materials
Journal Article
61 (1), e202109339 (2022)
Druggable allosteric sites in β-propeller lectins. Angewandte Chemie International Edition
Journal Article
5, 64 (2022)
Targeting undruggable carbohydrate recognition sites through focused fragment library design. Communications Chemistry
Journal Article
23 (3), e202100563 (2022)
Targeting the central pocket of the Pseudomonas aeruginosa lectin LecA. Chembiochem
Journal Article
13 (6), pp. 935 - 942 (2022)
Drug-like inhibitors of DC-SIGN based on a quinolone scaffold. ACS Medicinal Chemistry Letters
Journal Article
17 (10), pp. 2728 - 2733 (2022)
Identification of the allosteric binding site for thiazolopyrimidine on the C-type lectin langerin. ACS Chemical Biology 2021
Journal Article
141 (1), pp. 84 - 94.e6 (2021)
Notch-mediated generation of monocyte-derived Langerhans cells: phenotype and function. Journal of Investigative Dermatology
Journal Article
60 (24), pp. 13302 - 13309 (2021)
Automated glycan assembly of 19F labelled glycan probes enables high‐throughput NMR studies of protein‐glycan interactions. Angewandte Chemie International Edition
Journal Article
7 (3), pp. 624 - 635 (2021)
Impact of glycan linkage to staphylococcus aureus wall teichoic acid on langerin recognition and Langerhans cell activation. ACS Infectious Diseases
Journal Article
296, 100718 (2021)
The molecular basis for the pH-dependent calcium affinity of the pattern recognition receptor langerin. The Journal of Biological Chemistry
Journal Article
60 (15), pp. 8104 - 8114 (2021)
Non-carbohydrate glycomimetics as inhibitors of calcium(II)-binding lectins. Angewandte Chemie International Edition
Journal Article
12, 732298 (2021)
Specific protein antigen delivery to human Langerhans cells in intact skin. Frontiers in immunology
Journal Article
31 (2), pp. 159 - 165 (2021)
Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa. Glycobiology
Journal Article
143 (45), pp. 18977 - 18988 (2021)
A remote secondary binding pocket promotes heteromultivalent targeting of DC-SIGN. Journal of the American Chemical Society 2020
Journal Article
59 (47), pp. 21016 - 21022 (2020)
Rational design of an DNA-scaffolded high-affinity binder for langerin. Angewandte Chemie International Edition
Journal Article
62, pp. 31 - 38 (2020)
Allostery in C-type lectins. Current Opinion in Structural Biology
Journal Article
26 (44), pp. 9954 - 9963 (2020)
On-chip neo-glycopeptide synthesis for multivalent glycan presentation. Chemistry – A European Journal
Journal Article
63 (23), pp. 14780 - 14804 (2020)
From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement. Journal of Medicinal Chemistry
Journal Article
59 (6), pp. 2204 - 2210 (2020)
The 3F library: fluorinated Fsp3-rich fragments for expeditious 19F-NMR-based screening. Angewandte Chemie, International Edition
Journal Article
12 (2), pp. 191 - 200 (2020)
A common genetic variation in Langerin (CD207) compromises cellular uptake of Staphylococcus aureus. Journal of Innate Immunity 2019
Journal Article
7, 215 (2019)
Ranking Hits From Saturation Transfer Difference Nuclear Magnetic Resonance–Based Fragment Screening. Frontiers in Chemistry
Journal Article
2, 450 (2019)
Repression of phagocytosis by human CD33 is not conserved with mouse CD33. Communications Biology
Journal Article
25 (17), pp. 4478 - 4490 (2019)
Stereoselective synthesis of fluorinated galactopyranosides as potential molecular probes on galactophilic proteins: assessment of monofluorogalactosides-LecA interactions. Chemistry – A European Journal
Journal Article
9 (41), pp. 23484 - 23497 (2019)
Effects of linker and liposome anchoring on lactose-functionalized glycomacromolecules as multivalent ligands for binding galectin-3. RSC Advances
Journal Article
116 (6), pp. 1958 - 1967 (2019)
Microbe-focused glycan array screening platform. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
20 (11), pp. 4088 - 4095 (2019)
Asymmetrically branched precision glycooligomers targeting langerin. Biomacromolecules
Journal Article
58 (21), pp. 2576 - 2580 (2019)
A Liposomal Platform for Delivery of a Protein Antigen to Langerin-Expressing Cells. Biochemistry
Journal Article
10 (3), e00330-19 (2019)
Langerhans cells sense staphylococcus aureus wall teichoic acid through langerin to induce inflammatory responses. mBio
Journal Article
5 (5), pp. 808 - 820 (2019)
A specific, glycomimetic Langerin ligand for human Langerhans cell targeting. ACS Central Science 2018
Journal Article
140 (44), pp. 14915 - 14925 (2018)
Allosteric inhibition of a mammalian lectin. Journal of the American Chemical Society
Journal Article
26 (19), pp. 5368 - 5377 (2018)
Genetically-encoded fragment-based discovery of glycopeptide ligands for DC-SIGN. Bioorganic & Medicinal Chemistry
Journal Article
1862 (7), pp. 1592 - 1601 (2018)
High affinity sugar ligands of C-type lectin receptor langerin. Biochimica et Biophysica Acta (BBA) - General Subjects
Journal Article
13 (12), pp. 3229 - 3235 (2018)
CellFy: a cell-based fragment screen against C-type lectins. ACS Chemical Biology
Journal Article
140 (7), pp. 2537 - 2545 (2018)
Glycomimetic, orally bioavailable LecB inhibitors block biofilm formation of Pseudomonas aeruginosa. Journal of the American Chemical Society
Journal Article
8, 6625 (2018)
Synthesis and conformational analysis of linear homo- and heterooligomers from novel 2-C-branched sugar amino acids (SAAs). Scientific Reports 2017
Journal Article
56 (25), pp. 7292 - 7296 (2017)
Identification of multiple druggable secondary sites by fragment screening against DC-SIGN. Angewandte Chemie International Edition
Journal Article
312 (2), pp. L268 - L276 (2017)
A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models. American Journal of Physiology - Lung Cellular and Molecular Physiology
Journal Article
23 (64), pp. 16157 - 16161 (2017)
Increased conformational flexibility of a macrocycle‒receptor complex contributes to reduced dissociation rates. Chemistry – A European Journal
Journal Article
292 (3), pp. 862 - 871 (2017)
Bacterial polysaccharide specificity of the pattern recognition receptor langerin is highly species-dependent. The Journal of Biological Chemistry
Journal Article
18 (13), pp. 1183 - 1187 (2017)
Calcium-independent activation of an allosteric network in Langerin by heparin oligosaccharides. ChemBioChem: A European Journal of Chemical Biology
Journal Article
27 (1), pp. 80 - 86 (2017)
Saturation transfer difference nuclear magnetic resonance titrations reveal complex multistep-binding of l-fucose to norovirus particles. Glycobiology
Journal Article
139 (Supplement C), pp. 564 - 572 (2017)
Discovery of BAZ2A bromodomain ligands. European Journal of Medicinal Chemistry
Journal Article
27 (11), pp. 2472 - 2478 (2017)
Virtual screen to NMR (VS2NMR): discovery of fragment hits for the CBP bromodomain. Bioorganic & Medicinal Chemistry Letters 2016
Journal Article
52 (58), pp. 9067 - 9070 (2016)
Chemical fragment arrays for rapid druggability assessment. Chemical Communications
Journal Article
94 (11), pp. 920 - 926 (2016)
Fragment-screening of N-acetylmannosamine kinase reveals non-carbohydrate inhibitors. Canadian Journal of Chemistry
Journal Article
7, 11224 (2016)
Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans. Nature Communications
Journal Article
138 (37), pp. 12176 - 12186 (2016)
Intradomain allosteric network modulates calcium affinity of the C-Type lectin receptor langerin. Journal of the American Chemical Society
Journal Article
11 (9), pp. 2407 - 2413 (2016)
19F NMR-guided design of glycomimetic Langerin ligands. ACS Chemical Biology 2015
Journal Article
63 (2), pp. 116 - 121 (2015)
Fragmentbasierte Wirkstoffentwicklung. Nachrichten aus der Chemie
Journal Article
54, pp. 13796 - 13800 (2015)
Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angewandte Chemie International Edition 2014
Journal Article
Computational and experimental prediction of human C-type lectin receptor druggability. Frontiers in immunology, 5:323 (2014)
Journal Article
9 (4), pp. 867 - 873 (2014)
Epitope recognition of antibodies against a Yersinia pestis lipopolysaccharide trisaccharide component. ACS Chemical Biology
Journal Article
53 (9), pp. 2489 - 2493 (2014)
Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angewandte Chemie International Edition
Journal Article
136 (5), pp. 2008 - 2016 (2014)
Carbohydrate-lectin recognition of sequence-defined heteromultivalent glycooligomers. Journal of the American Chemical Society 2013
Journal Article
110 (19), pp. 7826 - 7831 (2013)
Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation. Proceedings of the National Academy of Sciences of the United States of America
Journal Article
123 (7), pp. 3074 - 3083 (2013)
Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis. The Journal of Clinical Investigation
Journal Article
8 (7), pp. 1417 - 1422 (2013)
On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7. ACS Chemical Biology 2012
Journal Article
51 (4), pp. 928 - 932 (2012)
Molecular Details of the Recognition of Blood Group Antigens by a Human Norovirus as Determined by STD NMR Spectroscopy. Angewandte Chemie International Edition
Journal Article
29 (7), pp. 491 - 502 (2012)
Small molecules containing hetero-bicyclic ring systems compete with UDP-Glc for binding to WaaG glycosyltransferase. Glycoconjugate Journal
Journal Article
134 (38), pp. 15696 - 15699 (2012)
In Silico-Aided Design of a Glycan Ligand of Sialoadhesin for in Vivo Targeting of Macrophages. Journal of the American Chemical Society
Journal Article
22 (8), pp. 1086 - 1091 (2012)
A Siglec-like sialic-acid-binding motif revealed in an adenovirus capsid protein. Glycobiology
Journal Article
7 (5), pp. 829 - 834 (2012)
Glycan fingerprints: calculating diversity in glycan libraries. ACS Chemical Biology
Journal Article
215, pp. 10 - 22 (2012)
More accurate 1JCH coupling measurement in the presence of 3JHH strong coupling in natural abundance. Journal of Magnetic Resonance 2011
Journal Article
3 (4), pp. 411 - 419 (2011)
CD22 Regulates Adaptive and Innate Immune Responses of B Cells. Journal of Innate Immunity
Journal Article
17 (27), pp. 7442 - 7453 (2011)
Targeting Norovirus Infection-Multivalent Entry Inhibitor Design Based on NMR Experiments. Chemistry – A European Journal
Journal Article
21 (17), pp. 5045 - 5049 (2011)
High affinity sialoside ligands of myelin associated glycoprotein. Bioorganic & Medicinal Chemistry Letters 2010
Journal Article
27 (3), pp. 349 - 358 (2010)
NMR-based exploration of the acceptor binding site of human blood group B galactosyltransferase with molecular fragments. Glycoconjugate Journal 2008
Journal Article
130 (11), pp. 3669 - 3675 (2008)
NMR experiments reveal the molecular basis of receptor recognition by a calicivirus. Journal of the American Chemical Society
Journal Article
273, pp. 183 - 202 (2008)
Molecular recognition of ligands by native viruses and virus-like particles as studied by NMR experiments. Topics in Current Chemistry-Series 2007
Journal Article
129 (34), pp. 10489 - 10502 (2007)
Ligand specificity of CS-35, a monoclonal antibody that recognizes mycobacterial lipoarabinomannan: a model system for oligofuranoside-protein recognition. Journal of the American Chemical Society 2006
Journal Article
NMR analysis of carbohydrate-protein interactions. Glycomics, pp. 12 - 30 (2006)
Book (1)
2014
Book
Carbohydrates as Drugs. Springer, Cham (2014), 237 pp.
Book Chapter (1)
2016
Book Chapter
232, pp. 73 - 89. Springer, Switzerland (2016)
High-throughput synthesis of diverse compound collections for lead discovery and optimization. In: Handbook of Experimental Pharmacology, Vol. Meeting Abstract (6)
2018
Meeting Abstract
28 (12), 185, pp. 1075 - 1076. Annual Meeting of the Society for Glycobiology, New Orleans, LA, November 05, 2018 - November 08, 2018. Oxford University Press, Oxford (2018)
Synthetic glycan analog libraries for the development of selective, high affinity ligands of siglecs and galectins. In Glycobiology, 2017
Meeting Abstract
47 (S2), p. 32 - 32. 47th Annual Meeting of the German Society for Immunology, Erlangen, Germany, September 12, 2017. Wiley-VCH, Weinheim (2017)
Skin Langerhans cells sense the human pathogen Staphylococcus aureus through the C-type lectin receptor langerin (CD207). In European Journal of Immunology, 2015
Meeting Abstract
282 Supplement 1 Ed., P15-027, p. 245 - 245. 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life, Berlin, Germany, July 04, 2015 - July 09, 2015. Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies, Oxford, UK (2015)
Towards small molecule-based targeted delivery to immune cells. In FEBS Journal, 2014
Meeting Abstract
248. 248th National Meeting of the American-Chemical-Society (ACS), San Francisco, CA, August 10, 2014 - August 14, 2014. (2014)
Druggability of mammalian C-type lectin receptors. In Abstracts of Papers of the American Chemical Society,
Meeting Abstract
24 (11), p. 1129 - 1129. Joint Meeting of the Society-for-Glycobiology (SFG) and the
Japanese-Society-of-Carbohydrate-Research (JSCR), Honolulu, HI, November 16, 2014 - November 19, 2014. Oxford University Press, Oxford (2014)
Deciphering glycan-antibody interactions: towards a carbohydrate-based vaccine against Clostridium difficile. In Glycobiology,
Meeting Abstract
24 (11), p. 1218 - 1218. Joint Meeting of the Society-for-Glycobiology (SFG) and the
Japanese-Society-of-Carbohydrate-Research (JSCR), Honolulu, HI, November 16, 2014 - November 19, 2014. (2014)
Binding of langerin/CD207 to keratan sulfate disaccharide, Gal (6SO3) β1, 4-GlcNAc (6SO3) and its triangle derivative in vitro and in vivo: possible drug targets for COPD (chronic obstructive pulmonary disease). In GLYCOBIOLOGY, Editorial (1)
2020
Editorial
8, 471 (2020)
Addressing roles for glycans in immunology using chemical biology. Frontiers in Chemistry