Selected Publications

Automated Glycan Assembly

1. Hahm, H.S.; Kawasaki, F.; Broecker, F.; Mietzsch, M.; Heilbronn, R.; Fukuda, M.; Seeberger, P.H.;
Automated glycan assembly of oligo-N-acetyllactosamine gly-can probes to characterize virus-glycan interactions;
Chem., 2017, in press.

2. Hahm, H.S.; Hurevich, M.; Seeberger, P.H.;
Automated assembly of oligosaccharides containing multiple cis-glycosidic linkages;
Nature Comm. 2016, 7, 12482.

3. Calin, O.; Eller, S.; Seeberger, P.H.;
Automated Polysaccharide Synthesis: As-sembly of a 30mer Mannoside;
Angew. Chem. Int. Ed. 2013, 52, 5862-5865.

4. Eller, S.; Collot, M.; Yin, J.; Hahm, H.-S.; Seeberger, P.H.;
Automated Solid-Phase Synthesis of Chondroitin Sulfate Glycosaminoglycans;
Angew. Chem. Int. Ed. 2013, 52, 5858-5861

5. Castagner, B.; Kröck, L.; Esposito, D.; Wang, C.-C.; Bindschädler, P.; Seeberger, P.H.;
Streamlined Access to Conjugation-Ready Glycans by Automated Synthesis;
Chem. Sci. 2012, 3, 1617-1622

6. Werz, D.B.; Castagner, B.; Seeberger, P.H.;
Automated Synthesis of the Tumor-Associated Carbohydrate Antigens Gb3 and Globo H: Incorporation of α -Galactosidic Linkages;
J. Am. Chem. Soc. 2007, 129, 2770-2771.

7. Love, K.R.; Seeberger, P.H.;
Automated Solid-Phase Synthesis of Protected Tumor-Associated Antigen and Blood Group Determinant Oligosaccharides;
Angew. Chem. Int. Ed. 2004, 43, 602-605.

8. Plante, O.J.; Palmacci, E.R.; Seeberger, P.H.;
Automated Solid-Phase Synthesis of Oligosaccharides;
Science 2001, 291, 1523-1527.

Synthetic Carbohydrate Methodology

1. Schumann, B.; Parameswarappa, S.G.; Lisboa, M.P.; Kottari, N.; Guidetti, F.; Pereira, C.L.; Seeberger, P.H.;
Nucleophile-directed Stereocontrol Over Glycosylations Using Geminal Difluorinated Nucleophiles;
Angew. Chem. Int. Ed. 2016, 55, 14431.

2. Matthies, S.; Stallforth, P.; Seeberger, P.H.;
Total Synthesis of Conjugation-Ready Legionaminic Acid;
J. Am. Chem. Soc. 2015, 137, 2848-2851

GPI Anchor: Synthesis and Chemical Biology

1. Santer, M.; Wehle, M.; Vilotijevic, I.; Lipowsky, R.; Seeberger, P.H.; Varon-Silva, D.;
"How Flexible is the Glycosylphosphatidylinositol (GPI) An-chor Glycan Back-bone? Challenges in Simulation Studies of Oligosaccharides";
J. Am. Chem. Soc. 2012, 134, 18964-18972.

2. Kamena, F.; Tamborrini, M.; Liu, X.; Kwon, Y.-U.; Thompson, F.; Pluschke, G.; Seeberger; P.H.;
Synthetic GPI array to study antitoxic malaria response;
Nature Chem. Bio., 2008, 4, 238-240.

3. Liu, X.; Kwon, Y.-U.; Seeberger, P.H.;
Convergent Chemical Synthesis of a Fully Lipidated Glycosylphosphatidylinositol Anchor of Plasmodium falciparum;
J. Am. Chem. Soc. 2005, 127, 5004-5005.

4. Schofield, L.; Hewitt, M.C.; Evans, K.; Siomos, M.A.; Seeberger, P.H.;
Synthetic GPI as a Candidate Anti-toxic Vaccine in a Model of Malaria;
Nature, 2002, 418, 785-789.

Vaccines Against Infectious Diseases

1. Parameswarappa, S.G.; Reppe, K.; Geissner, A.; Ménová, P.; Govindan, S.; Calow, A.D.J.; Wahlbrink, A.; Weishaupt, M.W.; Monnanda, B.P.; Bell, R.L.; Pirof-ski, L.-a.; Suttorp, N.; Sander, L.E.; Witzenrath, M.; Pereira, C.L.; Anish, C.; Seeberger, P.H.;
A semi-synthetic oligosaccharide conjugate vaccine candidate confers protection against Streptococcus pneumoniae serotype 3 infection;
Cell Chem. Bio. 2016, 23, 1407-1416.

2. Cavallari, M.; Stallforth, P.; Kalinichenko, A.; Rathwell, D.; Gronewold, T.M.A.;  Adibekian, A.; Mori, L.;  Landmann, R.; Seeberger, P.H.; De Libero, G.;
A lipid-carbohydrate conjugate vaccine elicits long-lasting anti-carbohydrate antibodies that protect against Streptococcus pneumoniae;
Nature Chem. Bio. 2014, 10, 950-956. 

3. Broecker, F.; Martin, C.E.; Anish, C.; Seeberger, P.H.;
Synthetic Lipoteichoic Ac-id Glycans are Vaccine Candidates to Protect from Clostridium difficile Infections;
Cell Chem. Bio. 2016, 23, 1014.

4. Broecker, F.; Hanske, J.; Martin, C.; Baek, J.Y.; Wahlbrink, A.; Wojcik, F.; Hart-mann, L.; Rademacher, C.; Anish, C.; Seeberger, P.H.;
Multivalent Display of Min-imal Clostridium difficile Glycan Epitopes Mimics Antigenic Properties of Larger Glycans;
Nature Comm. 2016, 7, 11224.

5. Pereira, C.L.; Geissner, A.; Anish, C.; Seeberger, P.H.;
Defining antigenic de-terminants of Streptococcus pneumoniae serotype 4 capsular polysaccharide by total synthesis;
Angew. Chem. Int. Ed. 2015, 54, 10016-10019.

6. Anish, C.; Guo, X.; Wahlbrink, A.; Seeberger, P.H.;
Plague Detection by Anti-carbohydrate Antibodies;
Angew. Chem. Int. Ed. 2013, 52, 9524-9528.

7. Martin, C.E.; Broecker, F.; Oberli, M.A.; Komor, J.; Mattner, J.; Anish, C.; Seeberger, P.H.;
Immunological Evaluation of a Synthetic Clostridium difficile Oli-gosaccharide Conjugate Vaccine Candidate and Identification of a Minimal Epitope;
J. Am. Chem. Soc. 2013, 135, 9713-9722.

8. Oberli, M.A.; Tamborrini, M.; Tsai, Y.-H.; Werz, D.B.; Horlacher, T.; Adibekian, A.; Gauss, D.; Möller, H.M.; Pluschke, G.; Seeberger, P.H.;
Molecular Analysis of Oligosaccharide-Antibody Interactions;
J. Am. Chem. Soc. 2010, 132, 10239-10241.

9. Werz, D.B.; Seeberger, P.H.;
First Total Synthesis of a Bacillus Anthracis Tetrasaccharide Antigen – Creation of an Anthrax Vaccine;
Angew. Chem. Int. Ed. 2005, 44, 6315-6318.

10. Tamborrini, M.; Werz, D. B.; Frey, J.; Pluschke, G.; Seeberger, P.H.;
Anti-Carbohydrate Antibodies for the Detection of Anthrax Spores;
Angew. Chem. Int. Ed. 2006, 45, 6581-6582.

Continuous Flow Chemistry

1. Correia, C.A.; Gilmore, K.; McQuade, D.T.; Seeberger, P.H.;
A Concise Flow Synthesis of Efavirenz;
Angew. Chem. Int. Ed. 2015, 54, 4945-4948.

2. Ghislieri, D.; Gilmore, K.; Seeberger, P.H.;
Chemical Assembly Systems: Layered Control for Divergent, Continuous, Multi-Step Syntheses of APIs;
Angew. Chem. Int. Ed. 2015, 54, 678-682

3. Ushakov, D.B.; Gilmore, K.; Kopetzki, D.; McQuade, T.D.; Seeberger, P.H.;
Continuous Flow Oxidative Cyanation of Primary and Secondary Amines Using Singlet Oxygen;
Angew. Chem. Int. Ed. 2014, 53, 557–561

4. O’Brien, A.G.; Horváth, Z.; Lévesque, F.; Lee, J.; Seidel-Morgenstern, A.; Seeberger, P.H.;
Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving bed chromatography;
Angew. Chem. Int. Ed. 2012, 51, 7028-7030

5. Levesque, F.; Seeberger, P.H.;
Continuous flow synthesis of the antimalarial drug artemisinin;
Angew. Chem. Int. Ed. 2012, 51, 1706-1709.

6. Kikkeri, R.; Laurino, P.; Odedra, A.; Seeberger, P.H.;
Microreactor Synthesis of Carbohydrate Functionalized Quantum Dots;
Angew. Chem. Int. Ed. 2010, 49, 2054-2057.

7. Gustafsson, T.; Pontén, F.; Seeberger, P.H.;
Trimethylaluminum Mediated Amide Bond Formation in a Continuous Flow Microreactor as Key to the Synthesis of Rimonabant and Efaproxiral;
Chem. Comm. 2008, 1100-1102.

8. Flögel, O.; Codée, J.D.C.; Seebach, D.; Seeberger, P.H.;
Microreactor Synthesis of β-Peptides;
Angew. Chem. Int. Ed. 2006, 45, 7000-7003.

9. Ratner, D.M., Murphy, E.R.; Jhunjhunwala, M.; Snyder, D.A; Jensen, K.F.; Seeberger, P.H.;
Microreactor-based Reaction Optimization in Organic Chemistry – Glycosylation as a Challenge;
Chem. Comm. 2005, 578-581.

10. Hofmann, J.; Hahm, H.S.; Seeberger, P.H.; Pagel, K.;
Identification of Carbohy-drate Anomers Using Ion Mobility-Mass Spectrometry;
Nature 2015, 526, 241-244.

Carbohydrate Materials

1. Qi, Z.; Bharate, P.; Lai, C.-H.; Ziem, B.; Böttcher, C.; Schulz, A.; Beckert, F.; Hatting, B.; Mülhaupt, R.; Seeberger, P.H.; Haag, R.;
Multivalency at an Interface: Supramolecular Carbohydrate-Functionalized Graphene Derivatives for Bacterial Capture, Release, and Disinfection;
Nano. Lett. 2015, 15, 6051-6057.

2. Farr, T.D.; Lai, C.-H.; Grünstein, D.; Orts-Gil, G.; Wang, C.-C.; Boehm-Sturm, P.; Seeberger, P.H.; Harms, C.;
Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin;
NanoLett 2014, 14; 2130-2134.

3. Grünstein, D.; Maglinao, M.; Kikkeri, R.; Collot, M.; Barylyuk, K.; Lepenies, B.; Kamena, F.; Zenobi, R.; Seeberger, P.H.;
Hexameric Supramolecular Scaffold Ori-ents Carbohydrates to Sense Bacteria;
J. Am. Chem. Soc. 2011, 133, 13957-13966.

4. Kikkeri, R.; Grünstein, D.; Seeberger, P.H.;
Lectin Biosensing Using Digital Ana-lysis of Ru(II)-Glycodendrimers;
J. Am. Chem. Soc. 2010, 132, 10230-10232.

5. Kikkeri, R.; Lepenies, B.; Adibekian, A.; Laurino, P.; Seeberger, P.H.;
In Vitro Imaging and In Vivo Liver Targeting with Carbohydrate Capped Quantum Dots;
J. Am. Chem. Soc. 2009, 131, 2110-2112.


1. Tsai, Y.-H.; Liu, X.; Seeberger, P.H.;
Chemical Biology of Glycosylphosphatidyl-inositol Anchors;
Angew. Chem. Int. Ed. 2012, 51, 11438-11456.

2. Seeberger, P.H.;
Automated Oligosaccharide Synthesis;
Chem Soc. Rev. 2008, 37, 19-28.

3. Seeberger, P.H.; Werz, D.B.;
Synthesis and Medical Applications of Oligosaccharides;
Nature 2007, 446, 1046-1051.

4. Geyer, K.; Codee, J.D.C.; Seeberger, P.H.;
Microreactors as Tools for Synthetic Chemists – The Chemists’ Round-Bottom Flask of the 21st Century?;
Chem. Eur. J. 2006, 12, 8434-8442.


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