Ausgewählte Publikationen

Automated Glycan Assembly

1.
Joseph, A. A. S.; Pardo-Vargas, A.; Seeberger, P. H.: Total synthesis of polysaccharides by automated glycan assembly. Journal of the American Chemical Society 142 (19), S. 8561 - 8564 (2020)
2.
Le Mai Hoang, K.; Pardo-Vargas, A.; Zhu, Y.; Yu, Y.; Loria, M.; Delbianco, M.; Seeberger, P. H.: Traceless photolabile linker expedites chemical synthesis of complex oligosaccharides by automated glycan assembly. Journal of the American Chemical Society 141 (22), S. 9079 - 9086 (2019)
3.
Hahm, H. S.; Schlegel, M. K.; Hurevich, M.; Eller, S.; Schuhmacher, F.; Hofmann, J.; Pagel, K.; Seeberger, P. H.: Automated glycan assembly using the Glyconeer 2.1 synthesizer. Proceedings of the National Academy of Sciences of the USA 114 (17), S. E3385 - E3389 (2017)
4.
Hahm, H. S.; Hurevich, M.; Seeberger, P. H.: Automated assembly of oligosaccharides containing multiple cis-glycosidic linkages. Nature Communications 7, 12482 (2016)
5.
Eller, S.; Collot, M.; Yin, J.; Hahm, H. S.; Seeberger, P. H.: Automated solid-phase synthesis of chondroitin sulfate glycosaminoglycans. Angewandte Chemie International Edition 52 (22), S. 5858 - 5861 (2013)
6.
Plante, O. J.; Palmacci, E. R.; Seeberger, P. H.: Automated solid-phase synthesis of oligosaccharides. Science 291 (5508), S. 1523 - 1527 (2001)

Synthetic Carbohydrate Methodology

7.
Chatterjee, S.; Moon, S.; Hentschel, F.; Gilmore, K.; Seeberger, P. H.: An empirical understanding of the glycosylation reaction. Journal of the American Chemical Society 140 (38), S. 11942 - 11953 (2018)
8.
Schumann, B.; Parameswarappa, S.; Lisboa, M. P.; Kottari, N.; Guidetti, F.; Pereira, C. L.; Seeberger, P. H.: Nucleophile-directed stereocontrol over glycosylations using geminal-difluorinated nucleophiles. Angewandte Chemie International Edition 55 (46), S. 14431 - 14434 (2016)
9.
Matthies, S.; Stallforth, P.; Seeberger, P. H.: Total synthesis of legionaminic acid as basis for serological studies. Journal of the American Chemical Society 137 (8), S. 2848 - 2851 (2015)

GPI Anchor: Synthesis and Chemical Biology

10.
Götze, S.; Azzouz, N.; Tsai, Y.-H.; Groß, U.; Reinhardt, A.; Anish, C.; Seeberger, P. H.; Silva, D. V.: Diagnosis of toxoplasmosis using a synthetic glycosylphosphatidylinositol glycan. Angewandte Chemie, International Edition in English 53 (50), S. 13701 - 13705 (2014)
11.
Wehle, M.; Vilotijevic, I.; Lipowsky, R.; Seeberger, P. H.; Varón Silva, D.; Santer, M.: Mechanical compressibility of the glycosylphosphatidylinositol (GPI) anchor backbone governed by independent glycosidic linkages. Journal of the American Chemical Society 134 (46), S. 18964 - 18972 (2012)
12.
Kamena, F.; Tamborrini, M.; Liu, X.; Kwon, Y.-U.; Thompson, F.; Pluschke, G.; Seeberger, P. H.: Synthetic GPI array to study antitoxic malaria response, Nature Chemical Biology 4, S. 238 - 240 (2008)
13.
Schofield, L.; Hewitt, M. C.; Evans, K.; Siomos, M.-A.; Seeberger, P. H.: Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria. Nature 418 (6899), S. 785 - 789 (2002)

Vaccines Against Infectious Diseases

14.
Kaplonek, P.; Khan, N.; Reppe, K.; Schumann, B.; Emmadi, M.; Lisboa, M. P.; Xu, F.-F.; Calow, A. D. J.; Parameswarappa, S. G.; Witzenrath, M. et al.; Pereira, C. L.; Seeberger, P. H.: Improving vaccines against Streptococcus pneumoniae using synthetic glycans. Proceedings of the National Academy of Sciences of the United States of America 115 (52), S. 13353 - 13358 (2018)
15.
Lisboa, M. P.; Khan, N.; Martin, C.; Xu, F.-F.; Reppe, K.; Geissner, A.; Govindan, S.; Witzenrath, M.; Pereira, C. L.; Seeberger, P. H.: Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5. Proceedings of the National Academy of Sciences of the United States of America 114 (42), S. 11063 - 11068 (2017)
16.
Seeberger, P. H.; Pereira, C. L.; Khan, N.; Xiao, G.; Diago-Navarro, E.; Reppe, K.; Opitz, B.; Fries, B. C.; Witzenrath, M.: A Semi-Synthetic Glycoconjugate Vaccine Candidate for Carbapenem-Resistant Klebsiella pneumoniae. Angewandte Chemie, International Edition in English 56 (45), S. 13973 - 13978 (2017)
17.
Emmadi, M.; Khan, N.; Lykke, L.; Reppe, K.; Parameswarappa, S.; Lisboa, M. P.; Wienhold, S.-M.; Witzenrath, M.; Pereira, C. L.; Seeberger, P. H.: A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease. Journal of the American Chemical Society 139 (41), S. 14783 - 14791 (2017)
18.
Schumann, B.; Hahm, H. S.; Parameswarappa, S. G.; Reppe, K.; Wahlbrink, A.; Govindan, S.; Kaplonek, P.; Pirofski, L.-a.; Witzenrath, M.; Chakkumkal, A. et al.; Pereira, C. L.; Seeberger, P. H.: A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine. Science Translational Medicine 9 (380), eaaf5347 (2017)
19.
Parameswarappa, S. G.; Reppe, K.; Geißner, A.; Ménová, P.; Govindan, S.; Calow, A. D. J.; Wahlbrink, A.; Weishaupt, M. W.; Monnanda, B. P.; Bell, R. et al.; Pirofski, L.-A.; Suttorp, N.; Sander, L.; Witzenrath, M.; Pereira, C. L.; Chakkumkal, A.; Seeberger, P. H.: A semi-synthetic oligosaccharide conjugate vaccine candidate confers protection against Streptococcus pneumoniae serotype 3 infection. Cell Chemical Biology 23 (11), S. 1407 - 1416 (2016)
20.
Cavallari, M.; Stallforth, P.; Kalinichenko, A.; Rathwell, D. C. K.; Gronewold, T. M. A.; Adibekian, A.; Mori, L.; Landmann, R.; Seeberger, P. H.; De Libero, G.: A semisynthetic carbohydrate-lipid vaccine that protects against S-pneumoniae in mice. Nature Chemical Biology 10 (11), S. 950 - 956 (2014)
21.
Bröcker, F.; Martin, C. E.; Wegner, E.; Mattner, J.; Baek, J. Y.; Pereira, C. L.; Chakkumkal, A.; Seeberger, P. H.: Synthetic lipoteichoic acid glycans are potential vaccine candidates to protect from Clostridium difficile infections. Cell Chemical Biology 23 (8), S. 1014 - 1022 (2016)
22.
Broecker, F.; Hanske, J.; Martin, C. E.; Baek, J. Y.; Wahlbrink, A.; Wojcik, F.; Hartmann, L.; Rademacher, C.; Chakkumkal, A.; Seeberger, P. H.: Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans. Nature Communications 7, 11224 (2016)
23.
Pereira, C. L.; Geißner, A.; Chakkumkal, A.; Seeberger, P. H.: Chemical synthesis elucidates the immunological importance of a pyruvate modification in the capsular polysaccharide of Streptococcus pneumoniae serotype 4. Angewandte Chemie International Edition 54, S. 10016 - 10019 (2015)
24.
Anish, C.; Guo, X. Q.; Wahlbrink, A.; Seeberger, P. H.: Plague detection by anti-carbohydrate antibodies. Angewandte Chemie International Edition 52 (36), S. 9524 - 9528 (2013)
25.
Oberli, M. A.; Tamborrini, M.; Tsai, Y. H.; Werz, D. B.; Horlacher, T.; Adibekian, A.; Gauss, D.; Möller, H. M.; Pluschke, G.; Seeberger, P. H.: Molecular analysis of carbohydrate-antibody interactions: case study using a Bacillus anthracis tetrasaccharide. Journal of the American Chemical Society 132 (30), S. 10239 - 10241 (2010)
26.
Tamborrini, M.; Werz, D. B.; Frey, J.; Pluschke, G.; Seeberger, P. H.: Anti-carbohydrate antibodies for the detection of anthrax spores. Angewandte Chemie International Edition 45 (39), S. 6581 - 6582 (2006)

Continuous Flow Chemistry

27.
Chatterjee, S.; Guidi, M.; Seeberger, P. H.; Gilmore, K.: Automated radial synthesis of organic molecules. Nature 579 (7799), S. 379 - 384 (2020)
28.
Triemer, S.; Gilmore, K.; Vu, G. T.; Seeberger, P. H.; Seidel-Morgenstern, A.: Literally green chemical synthesis of artemisinin from plant extracts. Angewandte Chemie International Edition 57 (19), S. 5525 - 5528 (2018)
29.
Correia, C. A.; Gilmore, K.; McQuade, D. T.; Seeberger, P. H.: A concise flow synthesis of Efavirenz. Angewandte Chemie International Edition 54 (16), S. 4945 - 4948 (2015)
30.
Ghislieri, D.; Gilmore, K.; Seeberger, P. H.: Chemical assembly systems: layered control for divergent, continuous, multistep syntheses of active pharmaceutical ingredients. Angewandte Chemie International Edition 54 (2), S. 678 - 682 (2015)
31.
O'Brien, A. G.; Horvath, Z.; Levesque, F.; Lee, J. W.; Seidel-Morgenstern, A.; Seeberger, P. H.: Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography. Angewandte Chemie International Edition 51 (28), S. 7028 - 7030 (2012)
32.
Levesque, F.; Seeberger, P. H.: Continuous-flow synthesis of the anti-malaria drug artemisinin. Angewandte Chemie International Edition 51 (7), S. 1706 - 1709 (2012)
33.
Kikkeri, R.; Laurino, P.; Odedra, A.; Seeberger, P. H.: Synthesis of carbohydrate-functionalized quantum dots in microreactors. Angewandte Chemie International Edition 49 (11), S. 2054 - 2057 (2010)

Carbohydrate Materials

34.
Wu, X.; Delbianco, M.; Anggara, K.; Michnowicz, T.; Pardo-Vargas, A.; Bharate, P.; Sen, S.; Pristl, M.; Rauschenbach, S.; Schlickum, U. et al.; Abb, S.; Seeberger, P. H.; Kern, K.: Imaging single glycans. Nature 582 (7812), S. 375 - 378 (2020)
35.
Yu, Y.; Tyrikos-Ergas, T.; Zhu, Y.; Fittolani, G.; Bordoni, V.; Singhal, A.; Fair, R. J.; Grafmüller, A.; Seeberger, P. H.; Delbianco, M.: Systematic hydrogen-bond manipulations to establish polysaccharide structure–property correlations. Angewandte Chemie International Edition in English 58 (37), S. 13127 - 13132 (2019)
36.
Delbianco, M.; Kononov, A.; Poveda, A.; Yu, Y.; Diercks, T.; Jiménez-Barbero, J.; Seeberger, P. H.: Well-defined oligo- and polysaccharides as ideal probes for structural studies. Journal of the American Chemical Society 140 (16), S. 5421 - 5426 (2018)
37.
Qi, Z.; Bharate, P.; Lai, C.-H.; Ziem, B.; Böttcher, C.; Schulz, A.; Beckert, F.; Hatting, B.; Mülhaupt, R.; Seeberger, P. H. et al.; Haag, R.: Multivalency at interfaces: supramolecular carbohydrate-functionalized graphene derivatives for bacterial capture, release, and disinfection. Nano Letters 15 (9), S. 6051 - 6057 (2015)
38.
Grünstein, D.; Maglinao, M.; Kikkeri, R.; Collot, M.; Barylyuk, K.; Lepenies, B.; Kamena, F.; Zenobi, R.; Seeberger, P. H.: Hexameric supramolecular scaffold orients carbohydrates to sense bacteria. Journal of the American Chemical Society 133 (35), S. 13957 - 13966 (2011)
39.
Kikkeri, R.; Lepenies, B.; Adibekian, A.; Laurino, P.; Seeberger, P. H.: In vitro imaging and in vivo liver targeting with carbohydrate capped quantum dots. Journal of the American Chemical Society 131, S. 2110 - 2112 (2009)

Glycobiology

40.
Roderer, D.; Bröcker, F.; Sitsel, O.; Kapłonek, P.; Leidreiter, F.; Seeberger, P. H.; Raunser, S.: Glycan-dependent cell adhesion mechanism of Tc toxins. Nature Communications 11, 2694 (2020)
41.
Mucha, E.; Marianski, M.; Xu, F.-F.; Thomas, D. A.; Meijer, G.; von Helden, G.; Seeberger, P. H.; Pagel, K.: Unravelling the structure of glycosyl cations via cold-ion infrared spectroscopy. Nature Communications 9, 4174 (2018)
42.
Gustafsen, C.; Olsen, D.; Vilstrup, J.; Lund, S.; Reinhardt, A.; Wellner, N.; Larsen, T.; Andersen, C. B.F.; Weyer, K.; Li, J.-p. et al.; Seeberger, P. H.; Thirup, S.; Madsen, P.; Glerup, S.: Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. Nature Communications 8, 503 (2017)
43.
Hofmann, J.; Hahm, H. S.; Seeberger, P. H.; Pagel, K.: Identification of carbohydrate anomers using ion mobility-mass spectrometry. Nature 526 (7572), S. 241 - 244 (2015)

Reviews

44.
Guberman, M.; Seeberger, P. H.: Automated Glycan Assembly: A Perspective. Journal of the American Chemical Society 141 (14), S. 5581 - 5592 (2019)
45.
Plutschack, M. B.; Pieber, B.; Gilmore, K.; Seeberger, P. H.: The Hitchhiker’s Guide to Flow Chemistry. Chemical Reviews 117 (18), S. 11796 - 11893 (2017)
46.
Tsai, Y. H.; Liu, X.; Seeberger, P. H.: Chemical biology of glycosylphosphatidylinositol anchors. Angewandte Chemie International Edition 51 (46), S. 11438 - 11456 (2012)
47.
Seeberger, P. H.; Werz, D. B.: Synthesis and medical applications of oligosaccharides. Nature 446 (7139), S. 1046 - 1051 (2007)

 

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