Ausgewählte Publikationen
Automated Glycan Assembly
Microwave-assisted automated glycan assembly. Journal of the American Chemical Society 143 (23), S. 8893 - 8901 (2021)
Total synthesis of polysaccharides by automated glycan assembly. Journal of the American Chemical Society 142 (19), S. 8561 - 8564 (2020)
Traceless photolabile linker expedites chemical synthesis of complex oligosaccharides by automated glycan assembly. Journal of the American Chemical Society 141 (22), S. 9079 - 9086 (2019)
Automated glycan assembly using the Glyconeer 2.1 synthesizer. Proceedings of the National Academy of Sciences of the USA 114 (17), S. E3385 - E3389 (2017)
Automated solid-phase synthesis of oligosaccharides. Science 291 (5508), S. 1523 - 1527 (2001)
Synthetic Carbohydrate Methodology
Towards a systematic understanding of the influence of temperature on glycosylation reactions. Angewandte Chemie International Edition 61 (15), e202115433 (2022)
Predicting glycosylation stereoselectivity using machine learning. Chemical Science 12 (8), S. 2931 - 2939 (2021)
An empirical understanding of the glycosylation reaction. Journal of the American Chemical Society 140 (38), S. 11942 - 11953 (2018)
Vaccines Against Infectious Diseases
Semi-synthetic glycoconjugate vaccine lead against Acinetobacter baumannii 17978. Angewandte Chemie International Edition 61 (41), e202209556 (2022)
Discovery of oligosaccharide antigens for semi-synthetic glycoconjugate vaccine leads against Streptococcus suis serotypes 2, 3, 9 and 14. Angewandte Chemie International Edition 60 (26), S. 14679 - 14692 (2021)
Improving vaccines against Streptococcus pneumoniae using synthetic glycans. Proceedings of the National Academy of Sciences of the United States of America 115 (52), S. 13353 - 13358 (2018)
A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumoniae. Angewandte Chemie International Edition 56 (45), S. 13973 - 13978 (2017)
A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine. Science Translational Medicine 9 (380), eaaf5347 (2017)
A semisynthetic carbohydrate-lipid vaccine that protects against S-pneumoniae in mice. Nature Chemical Biology 10 (11), S. 950 - 956 (2014)
Anti-carbohydrate antibodies for the detection of anthrax spores. Angewandte Chemie International Edition 45 (39), S. 6581 - 6582 (2006)
Continuous Flow Chemistry
Automated radial synthesis of organic molecules. Nature 579 (7799), S. 379 - 384 (2020)
Literally green chemical synthesis of artemisinin from plant extracts. Angewandte Chemie International Edition 57 (19), S. 5525 - 5528 (2018)
Chemical assembly systems: layered control for divergent, continuous, multistep syntheses of active pharmaceutical ingredients. Angewandte Chemie International Edition 54 (2), S. 678 - 682 (2015)
Continuous-flow synthesis of the anti-malaria drug artemisinin. Angewandte Chemie International Edition 51 (7), S. 1706 - 1709 (2012)
Carbohydrate Materials
Bottom-up approach to understand chirality transfer across scales in cellulose assemblies. Journal of the American Chemical Society 144 (27), S. 12469 - 12475 (2022)
Imaging single glycans. Nature 582 (7812), S. 375 - 378 (2020)
Systematic hydrogen-bond manipulations to establish polysaccharide structure–property correlations. Angewandte Chemie International Edition 58 (37), S. 13127 - 13132 (2019)
Well-defined oligo- and polysaccharides as ideal probes for structural studies. Journal of the American Chemical Society 140 (16), S. 5421 - 5426 (2018)
Multivalency at interfaces: supramolecular carbohydrate-functionalized graphene derivatives for bacterial capture, release, and disinfection. Nano Letters 15 (9), S. 6051 - 6057 (2015)
Glycobiology
Glycan-dependent cell adhesion mechanism of Tc toxins. Nature Communications 11, 2694 (2020)
Unravelling the structure of glycosyl cations via cold-ion infrared spectroscopy. Nature Communications 9, 4174 (2018)
Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. Nature Communications 8, 503 (2017)
Identification of carbohydrate anomers using ion mobility-mass spectrometry. Nature 526 (7572), S. 241 - 244 (2015)
Reviews
Discovery of semi- and fully-synthetic carbohydrate vaccines against bacterial infections using a medicinal chemistry approach. Chemical Reviews 121 (7), S. 3598 - 3626 (2021)
Automated glycan assembly: a perspective. Journal of the American Chemical Society 141 (14), S. 5581 - 5592 (2019)
The Hitchhiker’s guide to flow chemistry. Chemical Reviews 117 (18), S. 11796 - 11893 (2017)
Chemical biology of glycosylphosphatidylinositol anchors. Angewandte Chemie International Edition 51 (46), S. 11438 - 11456 (2012)