Ruprecht, C.; Geißner, A.; Seeberger, P. H.; Pfrengle, F.: Practical considerations for printing high-density glycan microarrays to study weak carbohydrate-protein interactions. Carbohydrate Research 481, pp. 31 - 35 (2019)
Baek, J. Y.; Geissner, A.; Rathwell, D. C. K.; Meierhofer, D.; Pereira, C. L.; Seeberger, P. H.: A modular synthetic route to size-defined immunogenic Haemophilus influenzae b antigens is key to the identification of an octasaccharide lead vaccine candidate. Chemical Science 9 (5), pp. 1279 - 1288 (2018)
Lisboa, M. P.; Khan, N.; Martin, C.; Xu, F.-F.; Reppe, K.; Geissner, A.; Govindan, S.; Witzenrath, M.; Pereira, C. L.; Seeberger, P. H.: Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5. Proceedings of the National Academy of Sciences of the United States of America 114 (42), pp. 11063 - 11068 (2017)
Geissner, A.; Seeberger, P. H.: Glycan arrays: from basic biochemical research to bioanalytical and biomedical applications. Annual Review of Analytical Chemistry 9 (1), pp. 223 - 247 (2016)
Pereira, C. L.; Geißner, A.; Chakkumkal, A.; Seeberger, P. H.: Chemical synthesis elucidates the immunological importance of a pyruvate modification in the capsular polysaccharide of Streptococcus pneumoniae serotype 4. Angewandte Chemie International Edition 54, pp. 10016 - 10019 (2015)
Geißner, A.; Anish, C.; Seeberger, P. H.: Glycan arrays as tools for infectious disease research. Current Opinion in Chemical Biology 18, pp. 38 - 45 (2014)
Pfrengle, F.; Schlegel, M. K.; Geissner, A.; Seeberger, P. H.: Automated solid-phase synthesis of oligoxylans. In Abstracts of Papers of the American Chemical Society, 248, CARB-47. 248th National Meeting of the American-Chemical-Society (ACS), San Francisco, CA, August 10, 2014 - August 14, 2014. Amer Chem Soc (2014)
Geißner, A.: Glycan arrays: From basic glycobiology to diagnostics and vaccine research. Dissertation, 246 pp., Freie Universität Berlin, Berlin (2017)
Michel, M.; Stijlemans, B.; Michel, D.; Garg, M.; Geißner, A.; Seeberger, P. H.; Varón Silva, D.: Detection of antibodies against the african parasite Trypanosoma brucei using synthetic glycosylphosphatidylinositol oligosaccharide fragments. bioRxiv: the preprint server for biology, 2023.12.31.573764 (2024)
Supported by the EU’s Marie Skłodowska-Curie Actions and the UK Guarantee Scheme, the 'Condensates at Membrane Scaffolds – Integrated Systems as Synthetic Cell Compartments’ doctoral network seeks 17 PhD candidates. This international and interdisciplinary program aims to train future biomedical and biotechnology researchers to explore cellular…
Scientists can now predict structural colors in bacteria. By sequencing a wide range of bacterial DNA and developing an accurate predictive model, reseachers uncovered how bacteria organize themselves into specific patterns within colonies to interfere with light and create iridescence.Their findings hold great promise for sustainable, pigment-free color production.
Biomolecular condensates may play a crucial but overlooked role in remodeling membrane structures within cells. Rumiana Dimova and her team demonstrated that these droplets can shape parts of the endoplasmic reticulum into nanotubes and double-membrane discs without the need for specific curvature-molding proteins.
Imagine switching on a light and being able to understand and control the inner dynamics of a cell. This is what the Dimova group has achieved: by shining lights of different colors on replicates of cells, they altered the interactions between cellular elements. Controlling these complex interactions enables us to deliver specific drugs directly into the cells.
Little is known yet about the interaction between these biomolecular condensate droplets and the membrane-bound organelles. Researchers at the Max Planck Institute of Colloids and Interfaces in Potsdam developed synthetic membraneless organelles and visualized what happens when they meet a membrane.
Prof Silvia Vignolini, Ph.D. is establishing the new Department "Sustainable and Bio-inspired Materials". She is working at the interface of physics, chemistry, biology and materials science and perfectly complements the institute's profile of research on chemistry, materials and sustainability.