Forschung
The research interests of the group can be roughly subdivided into three main -- sometimes overlapping -- categories.
In the framework of Statistics, Data analysis & Methods we were concerned with finding signals or patterns in the data and developing our own tools to analyze data. In Modeling & Theory we were concerned with the theoretical understanding of some processes and with the underlying mathematical aspects of the modeling. In Biology & Biophysics the specific biological questions and experimental methods stand on the foreground.
Current research projects are based on the application of artificial intelligence methods to modeling, classification, regression and statistics.
The publications listed below come from the research activity since 2015. Some publications are listed under more than one category.
Statistics, Data analysis & Methods
A neural networks approach for the analysis of reproducible ribo–seq profiles. Algorithms 15 (8), 274 (2022)
Critical steps of Plasmodium falciparum ookinete maturation. Frontiers in Microbiology 11, 269 (2020)
A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity. Journal of Experimental Medicine 217 (11), e20200061 (2020)
A workbench for the translational control of gene expression. bioRxiv (2020)
Time-resolved DNA release from an O-antigen–specific Salmonella bacteriophage with a contractile tail. Journal of Biological Chemistry 294 (31), S. 11751 - 11761 (2019)
Goodness of fit testing in dynamic single-molecule force spectroscopy. The Journal of Chemical Physics 149, 244120 (2018)
Integrative meta-analysis reveals that most yeast proteins are very stable. bioRxiv (2017)
Analyzing the spatial positioning of nuclei in polynuclear giant cells. Journal of Physics D: Applied Physics 50 (46), 464001 (2017)
Kinetic analysis of protein stability reveals age-dependent degradation. Cell 167 (3), S. 803 - 815.e21 (2016)
A conditional likelihood is required to estimate the selection coefficient in ancient DNA. Scientific Reports 6, 31561 (2016)
Predict or classify: the deceptive role of time-locking in brain signal classification. Scientific Reports 6, 28236 (2016)
Degradation parameters from pulse-chase experiments. PLoS One 11 (5), e0155028 (2016)
Quantitative assessment of ribosome drop-off in E. coli. Nucleic Acids Research 44 (6), S. 2528 - 2537 (2016)
Bacteria differently regulate mRNA abundance to specifically respond to various stresses. Philosophical Transactions of the Royal Society of London - Series A: Mathematical Physical and Engineering Sciences 374 (2063), 20150069 (2016)
Circular analysis in complex stochastic systems. Scientific Reports 5, 17986 (2015)
Single-molecule modeling of mRNA degradation by miRNA: lessons from data. BMC Systems Biology 9 (Suppl 3), S2 (2015)
Modeling & Theory
Stochastic modeling of complex macromolecular decay. In: Lectures in Pure and Applied Mathematics, Bd. 4, S. 1 - 28. Potsdam University Press, Potsdam (2017)
A conditional likelihood is required to estimate the selection coefficient in ancient DNA. Scientific Reports 6, 31561 (2016)
Predict or classify: the deceptive role of time-locking in brain signal classification. Scientific Reports 6, 28236 (2016)
Degradation parameters from pulse-chase experiments. PLoS One 11 (5), e0155028 (2016)
Circular analysis in complex stochastic systems. Scientific Reports 5, 17986 (2015)
Single-molecule modeling of mRNA degradation by miRNA: lessons from data. BMC Systems Biology 9 (Suppl 3), S2 (2015)
Weak correlation of starch and volume in synchronized photosynthetic cells. Physical Review E 91 (1), 012711 (2015)
On time duality for Markov chains. Stochastic Models 31 (1), S. 98 - 118 (2015)
A quasi random walk to model a biological transport process. Methodology and Computing in Applied Probability 17 (1), S. 125 - 137 (2015)
Biology & Biophysics
Bin-based visualization of cytokine-co-expression patterns of IL-10-producing CD4 T cell subsets. European Journal of Immunology 52 (10), S. 1684 - 1687 (2022)
Critical steps of Plasmodium falciparum ookinete maturation. Frontiers in Microbiology 11, 269 (2020)
A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity. Journal of Experimental Medicine 217 (11), e20200061 (2020)
A workbench for the translational control of gene expression. bioRxiv (2020)
Time-resolved DNA release from an O-antigen–specific Salmonella bacteriophage with a contractile tail. Journal of Biological Chemistry 294 (31), S. 11751 - 11761 (2019)
Integrative meta-analysis reveals that most yeast proteins are very stable. bioRxiv (2017)
Analyzing the spatial positioning of nuclei in polynuclear giant cells. Journal of Physics D: Applied Physics 50 (46), 464001 (2017)
The role of SufS is restricted to Fe−S cluster biosynthesis in Escherichia coli. Biochemistry 56 (14), S. 1987 - 2000 (2017)
Bacteria differently regulate mRNA abundance to specifically respond to various stresses. Philosophical Transactions of the Royal Society of London - Series A: Mathematical Physical and Engineering Sciences 374 (2063), 20150069 (2016)