Microarrays enable rapid high-throughput approaches to disease research, diagnostics, as well as materials discovery. The goal of our group is to generate highly complex microarrays, offering a multitude of different biomolecules or materials. With such arrays, we want to advance screening technology and find e.g. novel biomarkers for disease diagnostics or advanced materials for catalytic applications.

Our highly interdisciplinary research topics cover many different aspects of high-density arrays, their production technology, as well as their applications.

Technology Development & Applications

Our current research focuses on laser patterning technology. The approach unites the advantages of lithographic precision with rapid prototyping of recent 3d printing technology.

Exploiting this patterning technology, we strive to synthesize many different molecules and materials in a novel solid material-based organic synthesis approach. Combining our expertise in organic chemistry, materials science, and surface patterning with novel research questions, we can synthetically create the whole genomic information of a pathogen or generate new catalysts.

Together, we work in many different disciplines:

  1. Chemistry (surface chemistry, parallel organic synthesis)
  2. Materials Science (synthesis of composite materials, catalysts)
  3. Engineering (machine development, robotics, process automation)
  4. Physics (laser processing, simulation, machine learning)
  5. Biology, Biotechnology, Bioinformatics (protein interactions, infectious diseases)

Selected Publications

Tsouka, A.; Dallabernardina, P.; Mende, M.; Sletten, E. T.; Leichnitz, S.; Bienert, K.; Le Mai Hoang, K.; Seeberger, P. H.; Löffler, F. F.: VaporSPOT: parallel synthesis of oligosaccharides on membranes. Journal of the American Chemical Society 144 (43), pp. 19832 - 19837 (2022)
Zhang, J.; Zou, Y.; Eickelmann, S.; Njel, C.; Heil, T.; Ronneberger, S.; Strauß, V.; Seeberger, P. H.; Savateev, A.; Löffler, F. F.: Laser-driven growth of structurally defined transition metal oxide nanocrystals on carbon nitride photoelectrodes in milliseconds. Nature Communications 12, 3224 (2021)
Paris, G.; Heidepriem, J.; Tsouka, A.; Liu, Y.; Mattes, D. S.; Pinzón Martín, S.; Dallabernardina, P.; Mende, M.; Lindner, C.; Wawrzinek, R. et al.; Rademacher, C.; Seeberger, P. H.; Breitling, F.; Bischoff, F. R.; Wolf, T.; Löffler, F. F.: Automated laser-transfer synthesis of high-density microarrays for infectious disease screening. Advanced Materials 34 (12), 2200359 (2022)
Zhang, J.; Liu, Y.; Ronneberger, S.; Tarakina, N. V.; Merbouh, N.; Löffler, F. F.: Nanolayer laser absorber for femtoliter chemistry in polymer reactors. Advanced Materials 34 (8), 2108493 (2022)
Fathi, A.; Dahlke, C.; Krähling, V.; Kupke, A.; Okba, N. M. A.; Raadsen, M. P.; Heidepriem, J.; Müller, M. A.; Paris, G.; Lassen, S. et al.; Klüver, M.; Volz, A.; Koch, T.; Ly, M. L.; Friedrich, M.; Fux, R.; Tscherne, A.; Kalodimou, G.; Schmiedel, S.; Corman, V. M.; Hesterkamp, T.; Drosten, C.; Loeffler, F. F.; Haagmans, B. L.; Sutter, G.; Becker, S.; Addo, M. M.: Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome. Nature Communications 13, 4182 (2022)

Go to Editor View