Research

Research

Microarrays enable rapid high-throughput approaches to disease research, diagnostics, and drug discovery. The goal of our group is to generate highly complex microarrays, offering a multitude of different biomolecules. With such arrays, we want to advance screening technology and find e.g. novel biomarkers for disease diagnostics.

Our highly interdisciplinary research topics cover many different aspects of high-density arrays, their production technology, as well as their applications.

Technology Development & Applications

Our current technology research focuses on laser patterning technology. The approach unites the advantages of lithographic precision with rapid prototyping of recent 3d printing technology.

Exploiting this patterning technology, we strive to synthesize many different molecules in a novel solid material-based organic synthesis approach. Combining our expertise in organic chemistry and surface patterning with novel biological questions, we can synthetically create the whole genomic information of a pathogen. This allows us to screen e.g. the whole proteomes of different viruses to find novel diagnostic biomarkers.

We work in many different disciplines:

  1. Chemistry (surface chemistry, organic synthesis)
  2. Physics (laser processing, simulation)
  3. Biology, Biotechnology, Bioinformatics (protein interactions, infectious diseases)
  4. Engineering (machine development, robotics, process automation)
  5. Materials Science (synthesis of composite materials)

Selected Publications

1.
Mende, M.; Tsouka, A.; Heidepriem, J.; Paris, G.; Mattes, D. S.; Eickelmann, S.; Bordoni, V.; Wawrzinek, R.; Fuchsberger, F. F.; Seeberger, P. H. et al.; Rademacher, C.; Delbianco, M.; Mallagaray, A.; Löffler, F. F.: On-chip neo-glycopeptide synthesis for multivalent glycan presentation. Chemistry – A European Journal 26 (44), pp. 9954 - 9963 (2020)
2.
Paris, G.; Klinkusch, A.; Heidepriem, J.; Tsouka, A.; Zhang, J.; Mende, M.; Mattes, D.; Mager, D.; Riegler, H.; Eickelmann, S. et al.; Löffler, F. F.: Laser-induced forward transfer of soft material nanolayers with millisecond pulses shows contact-based material deposition. Applied Surface Science 508, 144973 (2020)
3.
Heidepriem, J.; Krähling, V.; Dahlke, C.; Wolf, T.; Klein, F.; Addo, M. M.; Becker, S.; Löffler, F. F.: Epitopes of naturally acquired and vaccine-induced anti-Ebola virus glycoprotein antibodies in single amino acid resolution. Biotechnology Journal 15 (9), 2000069 (2020)
4.
Eickelmann, S.; Tsouka, A.; Heidepriem, J.; Paris, G.; Zhang, J.; Molinari, V.; Mende, M.; Löffler, F. F.: A low-cost laser-based nano-3D polymer printer for rapid surface patterning and chemical synthesis of peptide and glycan microarrays. Advanced Materials Technologies 4 (11), 1900503 (2019)
5.
Zhang, J.; Gim, S.; Paris, G.; Dallabernardina, P.; Schmitt, C. N. Z.; Eickelmann, S.; Löffler, F. F.: Ultrasonic-assisted synthesis of highly defined silver nanodimers by self-assembly for improved surface-enhanced Raman spectroscopy. Chemistry – A European Journal 26 (6), pp. 1243 - 1248 (2020)

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