Research

Research

Microarrays enable rapid high-throughput approaches to disease research, diagnostics, as well as materials discovery. The goal of our group is to generate highly complex microarrays, offering a multitude of different biomolecules or materials. With such arrays, we want to advance screening technology and find e.g. novel biomarkers for disease diagnostics or advanced materials for catalytic applications.

Our highly interdisciplinary research topics cover many different aspects of high-density arrays, their production technology, as well as their applications.

Technology Development & Applications

Our current technology research focuses on laser patterning technology. The approach unites the advantages of lithographic precision with rapid prototyping of recent 3d printing technology.

Exploiting this patterning technology, we strive to synthesize many different molecules and materials in a novel solid material-based organic synthesis approach. Combining our expertise in organic chemistry, materials science, and surface patterning with novel research questions, we can synthetically create the whole genomic information of a pathogen or generate new catalysts.

Together, we work in many different disciplines:

  1. Chemistry (surface chemistry, organic synthesis)
  2. Materials Science (synthesis of composite materials, catalysts)
  3. Physics (laser processing, simulation)
  4. Engineering (machine development, robotics, process automation)
  5. Biology, Biotechnology, Bioinformatics (protein interactions, infectious diseases)

Selected Publications

1.
Zhang, J.; Liu, Y.; Ronneberger, S.; Tarakina, N. V.; Merbouh, N.; Löffler, F. F.: Nanolayer laser absorber for femtoliter chemistry in polymer reactors. Advanced Materials 34 (8), 2108493 (2022)
2.
Zhang, J.; Zou, Y.; Eickelmann, S.; Njel, C.; Heil, T.; Ronneberger, S.; Strauß, V.; Seeberger, P. H.; Savateev, A.; Löffler, F. F.: Laser-driven growth of structurally defined transition metal oxide nanocrystals on carbon nitride photoelectrodes in milliseconds. Nature Communications 12, 3224 (2021)
3.
Eickelmann, S.; Ronneberger, S.; Zhang, J.; Paris, G.; Löffler, F. F.: Alkanes as intelligent surface thermometers: a facile approach to characterize short-lived temperature gradients on the micrometer scale. Advanced Materials Interfaces 8 (3), 2001626 (2021)
4.
Eickelmann, S.; Tsouka, A.; Heidepriem, J.; Paris, G.; Zhang, J.; Molinari, V.; Mende, M.; Löffler, F. F.: A low-cost laser-based nano-3D polymer printer for rapid surface patterning and chemical synthesis of peptide and glycan microarrays. Advanced Materials Technologies 4 (11), 1900503 (2019)
5.
Heidepriem, J.; Dahlke, C.; Kobbe, R.; Santer, R.; Koch, T.; Fathi, A.; Silva Seco, B. M.; Ly, M. L.; Schmiedel, S.; Schwinge, D. et al.; Serna, S.; Sellrie, K.; Reichardt, N.-C.; Seeberger, P. H.; Addo, M. M.; Löffler, F. F.; ID-UKE COVID-19 Study: Longitudinal development of antibody responses in COVID-19 patients of different severity with ELISA, peptide, and glycan arrays: an immunological case series. Pathogens 10 (4), 438 (2021)

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