Publikationen
Zeitschriftenartikel (62)
2023
Zeitschriftenartikel
12, e69415 (2023)
Information transfer in mammalian glycan-based communication. eLife 2022
Zeitschriftenartikel
5 (5), S. 2185 - 2192 (2022)
Synthetic glyconanoparticles modulate innate immunity but not the complement system. ACS applied bio materials
Zeitschriftenartikel
34 (12), 2200359 (2022)
Automated laser-transfer synthesis of high-density microarrays for infectious disease screening. Advanced Materials
Zeitschriftenartikel
61 (1), e202109339 (2022)
Druggable allosteric sites in β-propeller lectins. Angewandte Chemie International Edition
Zeitschriftenartikel
5, 64 (2022)
Targeting undruggable carbohydrate recognition sites through focused fragment library design. Communications Chemistry
Zeitschriftenartikel
23 (3), e202100563 (2022)
Targeting the central pocket of the Pseudomonas aeruginosa lectin LecA. Chembiochem
Zeitschriftenartikel
13 (6), S. 935 - 942 (2022)
Drug-like inhibitors of DC-SIGN based on a quinolone scaffold. ACS Medicinal Chemistry Letters
Zeitschriftenartikel
17 (10), S. 2728 - 2733 (2022)
Identification of the allosteric binding site for thiazolopyrimidine on the C-type lectin langerin. ACS Chemical Biology 2021
Zeitschriftenartikel
141 (1), S. 84 - 94.e6 (2021)
Notch-mediated generation of monocyte-derived Langerhans cells: phenotype and function. Journal of Investigative Dermatology
Zeitschriftenartikel
60 (24), S. 13302 - 13309 (2021)
Automated glycan assembly of 19F labelled glycan probes enables high‐throughput NMR studies of protein‐glycan interactions. Angewandte Chemie International Edition
Zeitschriftenartikel
7 (3), S. 624 - 635 (2021)
Impact of glycan linkage to staphylococcus aureus wall teichoic acid on langerin recognition and Langerhans cell activation. ACS Infectious Diseases
Zeitschriftenartikel
296, 100718 (2021)
The molecular basis for the pH-dependent calcium affinity of the pattern recognition receptor langerin. The Journal of Biological Chemistry
Zeitschriftenartikel
60 (15), S. 8104 - 8114 (2021)
Non-carbohydrate glycomimetics as inhibitors of calcium(II)-binding lectins. Angewandte Chemie International Edition
Zeitschriftenartikel
12, 732298 (2021)
Specific protein antigen delivery to human Langerhans cells in intact skin. Frontiers in immunology
Zeitschriftenartikel
31 (2), S. 159 - 165 (2021)
Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa. Glycobiology
Zeitschriftenartikel
143 (45), S. 18977 - 18988 (2021)
A remote secondary binding pocket promotes heteromultivalent targeting of DC-SIGN. Journal of the American Chemical Society 2020
Zeitschriftenartikel
59 (47), S. 21016 - 21022 (2020)
Rational design of an DNA-scaffolded high-affinity binder for langerin. Angewandte Chemie International Edition
Zeitschriftenartikel
30 (30), 1905282 (2020)
Organic Light-Emitting Transistors: Advances and Perspectives. Advanced Functional Materials
Zeitschriftenartikel
62, S. 31 - 38 (2020)
Allostery in C-type lectins. Current Opinion in Structural Biology
Zeitschriftenartikel
26 (44), S. 9954 - 9963 (2020)
On-chip neo-glycopeptide synthesis for multivalent glycan presentation. Chemistry – A European Journal
Zeitschriftenartikel
63 (23), S. 14780 - 14804 (2020)
From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement. Journal of Medicinal Chemistry
Zeitschriftenartikel
59 (6), S. 2204 - 2210 (2020)
The 3F library: fluorinated Fsp3-rich fragments for expeditious 19F-NMR-based screening. Angewandte Chemie, International Edition
Zeitschriftenartikel
12 (2), S. 191 - 200 (2020)
A common genetic variation in Langerin (CD207) compromises cellular uptake of Staphylococcus aureus. Journal of Innate Immunity 2019
Zeitschriftenartikel
7, 215 (2019)
Ranking Hits From Saturation Transfer Difference Nuclear Magnetic Resonance–Based Fragment Screening. Frontiers in Chemistry
Zeitschriftenartikel
2, 450 (2019)
Repression of phagocytosis by human CD33 is not conserved with mouse CD33. Communications Biology
Zeitschriftenartikel
25 (17), S. 4478 - 4490 (2019)
Stereoselective synthesis of fluorinated galactopyranosides as potential molecular probes on galactophilic proteins: assessment of monofluorogalactosides-LecA interactions. Chemistry – A European Journal
Zeitschriftenartikel
9 (41), S. 23484 - 23497 (2019)
Effects of linker and liposome anchoring on lactose-functionalized glycomacromolecules as multivalent ligands for binding galectin-3. RSC Advances
Zeitschriftenartikel
116 (6), S. 1958 - 1967 (2019)
Microbe-focused glycan array screening platform. Proceedings of the National Academy of Sciences of the United States of America
Zeitschriftenartikel
20 (11), S. 4088 - 4095 (2019)
Asymmetrically branched precision glycooligomers targeting langerin. Biomacromolecules
Zeitschriftenartikel
58 (21), S. 2576 - 2580 (2019)
A Liposomal Platform for Delivery of a Protein Antigen to Langerin-Expressing Cells. Biochemistry
Zeitschriftenartikel
10 (3), e00330-19 (2019)
Langerhans cells sense staphylococcus aureus wall teichoic acid through langerin to induce inflammatory responses. mBio
Zeitschriftenartikel
5 (5), S. 808 - 820 (2019)
A specific, glycomimetic Langerin ligand for human Langerhans cell targeting. ACS Central Science
Zeitschriftenartikel
141 (12), S. 4833 - 4838 (2019)
Oligosaccharides self-assemble and show intrinsic optical properties. Journal of the American Chemical Society 2018
Zeitschriftenartikel
140 (44), S. 14915 - 14925 (2018)
Allosteric inhibition of a mammalian lectin. Journal of the American Chemical Society
Zeitschriftenartikel
26 (19), S. 5368 - 5377 (2018)
Genetically-encoded fragment-based discovery of glycopeptide ligands for DC-SIGN. Bioorganic & Medicinal Chemistry
Zeitschriftenartikel
1862 (7), S. 1592 - 1601 (2018)
High affinity sugar ligands of C-type lectin receptor langerin. Biochimica et Biophysica Acta (BBA) - General Subjects
Zeitschriftenartikel
13 (12), S. 3229 - 3235 (2018)
CellFy: a cell-based fragment screen against C-type lectins. ACS Chemical Biology
Zeitschriftenartikel
140 (7), S. 2537 - 2545 (2018)
Glycomimetic, orally bioavailable LecB inhibitors block biofilm formation of Pseudomonas aeruginosa. Journal of the American Chemical Society
Zeitschriftenartikel
8, 6625 (2018)
Synthesis and conformational analysis of linear homo- and heterooligomers from novel 2-C-branched sugar amino acids (SAAs). Scientific Reports 2017
Zeitschriftenartikel
56 (25), S. 7292 - 7296 (2017)
Identification of multiple druggable secondary sites by fragment screening against DC-SIGN. Angewandte Chemie International Edition
Zeitschriftenartikel
312 (2), S. L268 - L276 (2017)
A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models. American Journal of Physiology - Lung Cellular and Molecular Physiology
Zeitschriftenartikel
23 (64), S. 16157 - 16161 (2017)
Increased conformational flexibility of a macrocycle‒receptor complex contributes to reduced dissociation rates. Chemistry – A European Journal
Zeitschriftenartikel
292 (3), S. 862 - 871 (2017)
Bacterial polysaccharide specificity of the pattern recognition receptor langerin is highly species-dependent. The Journal of Biological Chemistry
Zeitschriftenartikel
18 (13), S. 1183 - 1187 (2017)
Calcium-independent activation of an allosteric network in Langerin by heparin oligosaccharides. ChemBioChem: A European Journal of Chemical Biology
Zeitschriftenartikel
27 (1), S. 80 - 86 (2017)
Saturation transfer difference nuclear magnetic resonance titrations reveal complex multistep-binding of l-fucose to norovirus particles. Glycobiology
Zeitschriftenartikel
139 (Supplement C), S. 564 - 572 (2017)
Discovery of BAZ2A bromodomain ligands. European Journal of Medicinal Chemistry
Zeitschriftenartikel
27 (11), S. 2472 - 2478 (2017)
Virtual screen to NMR (VS2NMR): discovery of fragment hits for the CBP bromodomain. Bioorganic & Medicinal Chemistry Letters 2016
Zeitschriftenartikel
52 (58), S. 9067 - 9070 (2016)
Chemical fragment arrays for rapid druggability assessment. Chemical Communications
Zeitschriftenartikel
94 (11), S. 920 - 926 (2016)
Fragment-screening of N-acetylmannosamine kinase reveals non-carbohydrate inhibitors. Canadian Journal of Chemistry
Zeitschriftenartikel
7, 11224 (2016)
Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans. Nature Communications
Zeitschriftenartikel
138 (37), S. 12176 - 12186 (2016)
Intradomain allosteric network modulates calcium affinity of the C-Type lectin receptor langerin. Journal of the American Chemical Society
Zeitschriftenartikel
6, 20488 (2016)
Cross Reactive Material 197 glycoconjugate vaccines contain privileged conjugation sites. Scientific Reports
Zeitschriftenartikel
11 (9), S. 2407 - 2413 (2016)
19F NMR-guided design of glycomimetic Langerin ligands. ACS Chemical Biology 2015
Zeitschriftenartikel
63 (2), S. 116 - 121 (2015)
Fragmentbasierte Wirkstoffentwicklung. Nachrichten aus der Chemie
Zeitschriftenartikel
10 (3), S. 575 - 579 (2015)
Drug discovery summit: 11th Swiss course on medicinal chemistry. ChemMedChem
Zeitschriftenartikel
54, S. 13796 - 13800 (2015)
Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angewandte Chemie International Edition 2014
Zeitschriftenartikel
Computational and experimental prediction of human C-type lectin receptor druggability. Frontiers in immunology, 5:323 (2014)
Zeitschriftenartikel
9 (4), S. 867 - 873 (2014)
Epitope recognition of antibodies against a Yersinia pestis lipopolysaccharide trisaccharide component. ACS Chemical Biology
Zeitschriftenartikel
53 (9), S. 2489 - 2493 (2014)
Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angewandte Chemie International Edition
Zeitschriftenartikel
136 (5), S. 2008 - 2016 (2014)
Carbohydrate-lectin recognition of sequence-defined heteromultivalent glycooligomers. Journal of the American Chemical Society 2013
Zeitschriftenartikel
8 (7), S. 1417 - 1422 (2013)
On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7. ACS Chemical Biology 2012
Zeitschriftenartikel
7 (5), S. 829 - 834 (2012)
Glycan fingerprints: calculating diversity in glycan libraries. ACS Chemical Biology Buch (1)
2014
Buch
Carbohydrates as Drugs. Springer, Cham (2014), 237 S.
Buchkapitel (1)
2016
Buchkapitel
232, S. 73 - 89. Springer, Switzerland (2016)
High-throughput synthesis of diverse compound collections for lead discovery and optimization. In: Handbook of Experimental Pharmacology, Bd. Meeting Abstract (6)
2018
Meeting Abstract
28 (12), 185, S. 1075 - 1076. Annual Meeting of the Society for Glycobiology, New Orleans, LA, 05. November 2018 - 08. November 2018. Oxford University Press, Oxford (2018)
Synthetic glycan analog libraries for the development of selective, high affinity ligands of siglecs and galectins. In Glycobiology, 2017
Meeting Abstract
47 (S2), S. 32 - 32. 47th Annual Meeting of the German Society for Immunology, Erlangen, Germany, 12. September 2017. Wiley-VCH, Weinheim (2017)
Skin Langerhans cells sense the human pathogen Staphylococcus aureus through the C-type lectin receptor langerin (CD207). In European Journal of Immunology, 2015
Meeting Abstract
282 Supplement 1 Aufl., P15-027, S. 245 - 245. 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life, Berlin, Germany, 04. Juli 2015 - 09. Juli 2015. Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies, Oxford, UK (2015)
Towards small molecule-based targeted delivery to immune cells. In FEBS Journal, 2014
Meeting Abstract
248. 248th National Meeting of the American-Chemical-Society (ACS), San Francisco, CA, 10. August 2014 - 14. August 2014. (2014)
Druggability of mammalian C-type lectin receptors. In Abstracts of Papers of the American Chemical Society,
Meeting Abstract
24 (11), S. 1129 - 1129. Joint Meeting of the Society-for-Glycobiology (SFG) and the
Japanese-Society-of-Carbohydrate-Research (JSCR), Honolulu, HI, 16. November 2014 - 19. November 2014. Oxford University Press, Oxford (2014)
Deciphering glycan-antibody interactions: towards a carbohydrate-based vaccine against Clostridium difficile. In Glycobiology,
Meeting Abstract
24 (11), S. 1218 - 1218. Joint Meeting of the Society-for-Glycobiology (SFG) and the
Japanese-Society-of-Carbohydrate-Research (JSCR), Honolulu, HI, 16. November 2014 - 19. November 2014. (2014)
Binding of langerin/CD207 to keratan sulfate disaccharide, Gal (6SO3) β1, 4-GlcNAc (6SO3) and its triangle derivative in vitro and in vivo: possible drug targets for COPD (chronic obstructive pulmonary disease). In GLYCOBIOLOGY, Hochschulschrift - Doktorarbeit (6)
2023
Hochschulschrift - Doktorarbeit
Novel chemotypes for inhibition of bacterial and mammalian carbohydrate-binding proteins. Dissertation, Freie Universität, Berlin (2023)
2021
Hochschulschrift - Doktorarbeit
Quantification of C-type lectin receptors signal transduction. Dissertation, 104 S., Freie Universtität, Berlin (2021)
2018
Hochschulschrift - Doktorarbeit
Towards Langerhans cell immune modulation: From ligand identification to antigen delivery and what we can learn from nature. Dissertation, 194 S., Freie Universität, Berlin (2018)
2017
Hochschulschrift - Doktorarbeit
Glycomimetic langerin ligands for Langerhans cell targeting. Dissertation, 320 S., Freie Universität Berlin, Berlin (2017)
2016
Hochschulschrift - Doktorarbeit
Fragment-based design of novel lectin ligands. Dissertation, 251 S., Freie Universität Berlin, Berlin (2016)
Hochschulschrift - Doktorarbeit
Investigation of the structural basis of ligand recognition of the C-type lectin receptor Langerin. Dissertation, 170 S., Freie Universität Berlin, Berlin (2016)
Editorial (1)
2020
Editorial
8, 471 (2020)
Addressing roles for glycans in immunology using chemical biology. Frontiers in Chemistry